Role of transglutaminase 2 in promoting biglycan synthesis in idiopathic gingival fibromatosis

被引：0
|
作者：
Ninomiya, Yurika [1 ]
Matsuda, Shinji [1 ]
Suzuki, Shigeki [2 ,3 ]
Hirata-Tsuchiya, Shizu [4 ]
Ueda, Tomoya [1 ]
Nakashima, Fuminori [1 ]
Yasuda, Keisuke [1 ]
Shimada, Shogo [1 ]
Memida, Takumi [5 ]
Yoshimoto, Tetsuya [6 ]
Yamada, Satoru [2 ]
Ouhara, Kazuhisa [1 ]
Mizuno, Noriyoshi [1 ]
机构：
[1] Hiroshima Univ, Grad Sch Biomed & Hlth Sci, Dept Periodontal Med, 1-2-3 Kasumi,Minami Ku, Hiroshima 7348553, Japan
[2] Tohoku Univ, Grad Sch Dent, Dept Periodontol & Endodontol, Sendai, Japan
[3] Okayama Univ, Grad Sch Med, Dept Operat Dent Dent & Pharmaceut Sci, Sendai, Japan
[4] Hiroshima Univ, Grad Sch Biomed & Hlth Sci, Dept Biol Endodont, Hiroshima, Japan
[5] Nova Southeastern Univ, Coll Dent Med, Dept Oral Sci & Translat Res, Ft Lauderdale, FL USA
[6] Hiroshima Univ Hosp, Ctr Oral Clin Examinat, Hiroshima, Japan
来源：
BMC ORAL HEALTH | 2024年 / 24卷 / 01期
关键词：
Idiopathic gingival fibromatosis; Periodontitis; Human gingival fibroblast; Transglutaminase; 2; Biglycan; Specific protein 1; PERIOSTIN;
D O I：
10.1186/s12903-024-05211-8
中图分类号：
R78 [口腔科学];
学科分类号：
1003 ;
摘要：
BackgroundThis study aimed to elucidate the pathogenesis of idiopathic gingival fibromatosis (IGF).MethodsHuman gingival fibroblasts (hGFs) were isolated from patients with IGF and periodontitis. Differential gene expression in the hGFs was analyzed using RNA sequencing. Extracellular matrix-related gene expression in the hGFs was analyzed. The effect of specific protein (SP)1 inhibitor or recombinant human transglutaminase 2 (rh-TGM2) on biglycan (BGN) expression in hGFs was also determined.ResultsRNA sequencing showed that TGM2 expression was downregulated and BGN mRNA expression was upregulated in patients with IGF relative to periodontitis. rh-TGM2 stimulation of hGFs in patients with IGF significantly reduced BGN expression. SP1 inhibitors downregulated BGN expression in the hGFs.ConclusionBGN upregulation via SP1 causes TGM2 downregulation in gingival fibroblasts in IGF.
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页数：10
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