Role of transglutaminase 2 in promoting biglycan synthesis in idiopathic gingival fibromatosis

被引：0
|
作者：
Ninomiya, Yurika [1 ]
Matsuda, Shinji [1 ]
Suzuki, Shigeki [2 ,3 ]
Hirata-Tsuchiya, Shizu [4 ]
Ueda, Tomoya [1 ]
Nakashima, Fuminori [1 ]
Yasuda, Keisuke [1 ]
Shimada, Shogo [1 ]
Memida, Takumi [5 ]
Yoshimoto, Tetsuya [6 ]
Yamada, Satoru [2 ]
Ouhara, Kazuhisa [1 ]
Mizuno, Noriyoshi [1 ]
机构：
[1] Hiroshima Univ, Grad Sch Biomed & Hlth Sci, Dept Periodontal Med, 1-2-3 Kasumi,Minami Ku, Hiroshima 7348553, Japan
[2] Tohoku Univ, Grad Sch Dent, Dept Periodontol & Endodontol, Sendai, Japan
[3] Okayama Univ, Grad Sch Med, Dept Operat Dent Dent & Pharmaceut Sci, Sendai, Japan
[4] Hiroshima Univ, Grad Sch Biomed & Hlth Sci, Dept Biol Endodont, Hiroshima, Japan
[5] Nova Southeastern Univ, Coll Dent Med, Dept Oral Sci & Translat Res, Ft Lauderdale, FL USA
[6] Hiroshima Univ Hosp, Ctr Oral Clin Examinat, Hiroshima, Japan
来源：
BMC ORAL HEALTH | 2024年 / 24卷 / 01期
关键词：
Idiopathic gingival fibromatosis; Periodontitis; Human gingival fibroblast; Transglutaminase; 2; Biglycan; Specific protein 1; PERIOSTIN;
D O I：
10.1186/s12903-024-05211-8
中图分类号：
R78 [口腔科学];
学科分类号：
1003 ;
摘要：
BackgroundThis study aimed to elucidate the pathogenesis of idiopathic gingival fibromatosis (IGF).MethodsHuman gingival fibroblasts (hGFs) were isolated from patients with IGF and periodontitis. Differential gene expression in the hGFs was analyzed using RNA sequencing. Extracellular matrix-related gene expression in the hGFs was analyzed. The effect of specific protein (SP)1 inhibitor or recombinant human transglutaminase 2 (rh-TGM2) on biglycan (BGN) expression in hGFs was also determined.ResultsRNA sequencing showed that TGM2 expression was downregulated and BGN mRNA expression was upregulated in patients with IGF relative to periodontitis. rh-TGM2 stimulation of hGFs in patients with IGF significantly reduced BGN expression. SP1 inhibitors downregulated BGN expression in the hGFs.ConclusionBGN upregulation via SP1 causes TGM2 downregulation in gingival fibroblasts in IGF.
引用
收藏
页数：10
相关论文
共 50 条
  • [1] Idiopathic Gingival Fibromatosis in a Pediatric Patient
    Abraham, K. Korath
    Ambooken, Majo
    Mangalathu, Arun George
    Jose, Sherin C.
    Mathews, Sneha Elizabeth
    JOURNAL OF DENTISTRY FOR CHILDREN, 2022, 89 (01) : 41 - 45
  • [2] Idiopathic gingival fibromatosis: A case report
    Lobao, Denise S.
    Silva, Luis Candido P.
    Soares, Rodrigo V.
    Cruz, Roberval A.
    QUINTESSENCE INTERNATIONAL, 2007, 38 (08): : 699 - 704
  • [3] Idiopathic Gingival Fibromatosis: Report of a Rare Case
    Abiraami, N. S. Shree
    Umamaheswari, T. N.
    Ramalingam, Karthikeyan
    Pillai, Devika S.
    CUREUS JOURNAL OF MEDICAL SCIENCE, 2024, 16 (08)
  • [4] Management of Idiopathic Gingival Fibromatosis: Report of a Case and Literature Review
    Ramnarayan, B. K.
    Sowmya, Krishna
    Rema, J.
    PEDIATRIC DENTISTRY, 2011, 33 (05) : 431 - 436
  • [5] Morphological and molecular analysis of idiopathic gingival fibromatosis: a case report
    Gagliano, N
    Moscheni, C
    Dellavia, C
    Masiero, S
    Torri, C
    Grizzi, F
    Stabellini, G
    Gioia, M
    JOURNAL OF CLINICAL PERIODONTOLOGY, 2005, 32 (10) : 1116 - 1121
  • [6] Idiopathic gingival fibromatosis and primary analysis of dominant bacteria in subgingival biofilm: a case report
    Zhu, Jingli
    Fan, Xinyue
    Ding, Lili
    Song, Tianzhu
    JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, 2024, 52 (04)
  • [7] Increase in transglutaminase 2 in idiopathic inflammatory myopathies
    Choi, YC
    Kim, TS
    Kim, SY
    EUROPEAN NEUROLOGY, 2004, 51 (01) : 10 - 14
  • [8] Role of glycosaminoglycans of biglycan in BMP-2 signaling
    Miguez, P. A.
    Terajima, M.
    Nagaoka, H.
    Mochida, Y.
    Yamauchi, M.
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2011, 405 (02) : 262 - 266
  • [9] A 15-year Follow-Up of a Gingivectomy Procedure for Idiopathic Gingival Fibromatosis: A Case Report and Literature Review
    Seki, Keisuke
    Sato, Shuichi
    JOURNAL OF CLINICAL PEDIATRIC DENTISTRY, 2022, 46 (02) : 119 - 124
  • [10] Transglutaminase 2 expression is significantly increased in cyclosporine-induced gingival overgrowth
    Asioli, Sofia
    Righi, Alberto
    Cardone, Pietro
    Aimetti, Mario
    Maletta, Francesca
    Coda, Renato
    Carossa, Stefano
    Navone, Roberto
    Cassoni, Paola
    HISTOLOGY AND HISTOPATHOLOGY, 2011, 26 (11) : 1399 - 1404
12345