Quantitative detection of macular microvascular abnormalities identified by optical coherence tomography angiography in different hematological diseases

被引：0

作者：

Jian, Tianzi ^{[1
]}

Xu, Fabao ^{[2
]}

Li, Guihua ^{[3
]}

Song, Boxuan ^{[2
]}

Wang, Helei ^{[2
]}

Yang, Xueying ^{[2
]}

Zhai, Weibin ^{[2
]}

Li, Xiangchen ^{[4
]}

Li, Zhiwen ^{[2
]}

Feng, Qi ^{[1
]}

Xu, Shuqian ^{[1
]}

Semple, John W. ^{[5
,6
,7
,8
,9
]}

Zhang, Li ^{[10
]}

Peng, Jun ^{[1
,11
]}

机构：

[1] Shandong Univ, Qilu Hosp, Dept Hematol, Jinan, Peoples R China

[2] Shandong Univ, Qilu Hosp, Dept Ophthalmol, Jinan, Peoples R China

[3] Binzhou Med Univ, Zibo Cent Hosp, Zibo, Shandong, Peoples R China

[4] Univ Manchester, Dept Comp Sci, Manchester, England

[5] Lund Univ, Div Hematol & Transfus Med, Lund, Sweden

[6] Off Med Serv, Clin Immunol & Transfus Med, Lund, Skane, Sweden

[7] Univ Toronto, Dept Pharmacol, Toronto, ON, Canada

[8] Univ Toronto, Dept Med & Lab Med, Toronto, ON, Canada

[9] Univ Toronto, Dept Pathobiol, Toronto, ON, Canada

[10] Huazhong Univ Sci & Technol, Cent Hosp Wuhan, Tongji Med Coll, Dept Ophthalmol, Wuhan, Hubei, Peoples R China

[11] Shandong Univ, Qilu Hosp, Cheeloo Coll Med, Dept Hematopathy, Jinan, Peoples R China

来源：

SCIENTIFIC REPORTS | 2024年 / 14卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Optical coherence tomography angiography; Myelocyte diseases; Erythrocyte diseases; Lymphocyte diseases; Pancytopenia diseases; RETINA; ANEMIA; IMAGES;

D O I：

10.1038/s41598-024-76753-8

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

It is now understood that hematological diseases can have detrimental effects on the retina, reducing retinal capillaries, compromising visual function, and potentially causing irreversible visual impairment. Over the years, there has been limited research on macular microvascular abnormalities, such as changes in vessel density and the foveal avascular zone (FAZ) and variations in the severity of these effects across different types of blood disorders. This study aims to quantitatively assess the impact of various hematological disorders on the retina using optical coherence tomography angiography (OCTA). Compared with healthy eyes, patients with different blood diseases exhibited reductions in linear vessel density (LVD), perfusion vessel density (PVD), FAZ area, and FAZ perimeter. Notably, patients with erythrocyte diseases showed more significant abnormalities in LVD and PVD, while patients with lymphocytic diseases demonstrated more pronounced abnormalities in the FAZ area and perimeter. OCTA imaging could potentially reflect changes of the retinal microvascular of patients with hematological diseases and may serve as a valuable tool for distinguishing abnormalities affecting different blood cell lines. This approach offers a novel avenue for assessing, treating, and monitoring blood disorders.

引用

页数：10

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