Association between gut microbiota and locomotive syndrome risk in healthy Japanese adults: a cross-sectional study

被引:0
|
作者
Nishiyama, Minami [1 ,2 ]
Nakamura, Sho [1 ,2 ,3 ]
Matsuki, Taizo [1 ,2 ]
Narimatsu, Hiroto [1 ,2 ,3 ]
机构
[1] Kanagawa Univ Human Serv, Grad Sch Hlth Innovat, Kawasaki, Kanagawa, Japan
[2] Kanagawa Canc Ctr Res Inst, Canc Prevent & Control Div, Yokohama, Kanagawa, Japan
[3] Kanagawa Canc Ctr, Dept Med Genet, Yokohama, Kanagawa, Japan
来源
NPJ AGING | 2024年 / 10卷 / 01期
基金
日本学术振兴会;
关键词
D O I
10.1038/s41514-024-00184-y
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
This cross-sectional study examined the association between gut microbiota composition and locomotive syndrome in 568 healthy Japanese adults (36.8% male, median age 58.5 years) using data from the Kanagawa "ME-BYO" Prospective Cohort Study. Locomotive syndrome was assessed using the 5-question Geriatric Locomotive Function Scale (GLFS-5). Linear discriminant analysis effect size showed an enrichment of Actinobacteria and depletion of Firmicutes in GLFS-5 positive individuals. Classification tree analysis identified three terminal nodes as GLFS-5 positive, with one node involving Holdemania. Participants aged >= 70.0 and <78.0 years who did not consume probiotic foods and had >= 0.04% relative abundance of Holdemania were classified as at risk for locomotive syndrome. Our findings suggest a potential association between gut microbiota, particularly higher Holdemania abundance, and locomotive syndrome in older adults. This study provides insights into the complex relationship between gut microbiome composition and musculoskeletal health in aging populations. However, the cross-sectional design limits causal inference.
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页数:9
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