Advances and applications of RNA vaccines in tumor treatment

被引：12

作者：

Yang, Ruohan ^{[1
]}

Cui, Jiuwei ^{[1
]}

机构：

[1] First Hosp Jilin Univ, Canc Ctr, Changchun 130021, Peoples R China

来源：

MOLECULAR CANCER | 2024年 / 23卷 / 01期

基金：

中国国家自然科学基金;

关键词：

CIRCULAR RNAS; LIPID NANOPARTICLES; NEOANTIGEN VACCINE; IMMUNE-RESPONSES; IN-VITRO; T-CELLS; EXPRESSION; INNATE; SELF; DELIVERY;

D O I：

10.1186/s12943-024-02141-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Compared to other types of tumor vaccines, RNA vaccines have emerged as promising alternatives to conventional vaccine therapy due to their high efficiency, rapid development capability, and potential for low-cost manufacturing and safe drug delivery. RNA vaccines mainly include mRNA, circular RNA (circRNA), and Self-amplifying mRNA(SAM). Different RNA vaccine platforms for different tumors have shown encouraging results in animal and human models. This review comprehensively describes the advances and applications of RNA vaccines in antitumor therapy. Future directions for extending this promising vaccine platform to a wide range of therapeutic uses are also discussed.

引用

页数：12

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