Neoadjuvant immune checkpoint inhibitors for hepatocellular carcinoma

被引：1

作者：

Akula, Vinita ^{[1
]}

Chen, Lily ^{[1
]}

Acikgoz, Yusuf ^{[2
]}

Klein, Katherine ^{[1
]}

Yavuz, Betul Gok ^{[3
]}

Cevik, Lokman ^{[4
]}

Demir, Tarik ^{[5
]}

Manne, Ashish ^{[2
]}

Sahin, Ilyas ^{[6
]}

Kaseb, Ahmed ^{[7
]}

Hasanov, Elshad ^{[2
]}

机构：

[1] Univ Texas, Dept Internal Med, Hlth Sci Ctr, Houston UTHealth, Houston, TX USA

[2] Ohio State Univ, Comprehens Canc Ctr, Dept Internal Med, Div Med Oncol, Columbus, OH 43210 USA

[3] Univ Missouri, Dept Med, Columbia, MO USA

[4] Ohio State Univ, Wexner Med Ctr, Dept Pathol, Columbus, OH USA

[5] Northwestern Univ, Div Hematol & Oncol Dev Therapeut Inst, Chicago, IL USA

[6] Univ Florida, Dept Med, Div Hematol & Oncol, Gainesville, FL USA

[7] Univ Texas, Dept Gastrointestinal Med Oncol, MD Anderson Canc Ctr, Houston, TX USA

来源：

NPJ PRECISION ONCOLOGY | 2025年 / 9卷 / 01期

关键词：

CAMRELIZUMAB PLUS APATINIB; OPEN-LABEL; DOUBLE-BLIND; SINGLE-ARM; RECURRENCE; RESECTION; SORAFENIB; CANCER; TRIAL; HCC;

D O I：

10.1038/s41698-025-00846-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hepatocellular carcinoma (HCC) is the most common type of liver cancer. HCC treatment is challenging; surgical resection is the primary curative treatment for early-stage disease, but recurrence rates are high. Immune checkpoint inhibitors (ICIs) are a promising neoadjuvant treatment that can reduce recurrence rates and mortality after surgery and achieve complete/partial responses. Clinical trials provide strong evidence for the efficacy and safety of ICI monotherapy for neoadjuvant HCC treatment.

引用

页数：13

共 50 条

[31] Clinical Trials of Immune Checkpoint Inhibitors in Hepatocellular Carcinoma
Dyhl-Polk, Anne
Mikkelsen, Marta Kramer
Ladekarl, Morten
Nielsen, Dorte Lisbet
JOURNAL OF CLINICAL MEDICINE, 2021, 10 (12)
[32] Immune Checkpoint Inhibitors in Hepatocellular Carcinoma: Opportunities and Challenges
Liu, Xiufeng
Qin, Shukui
ONCOLOGIST, 2019, 24 : S3 - S10
[33] Current progress of immune checkpoint inhibitors in the treatment of advanced hepatocellular carcinoma
Yin, Xiaoqiang
Wu, Tongchui
Lan, Yadong
Yang, Wulin
BIOSCIENCE REPORTS, 2022, 42 (02)
[34] Immune Checkpoint Inhibitors in Hepatocellular Carcinoma: Current Status and Novel Perspectives
Federico, Piera
Petrillo, Angelica
Giordano, Pasqualina
Bosso, Davide
Fabbrocini, Antonietta
Ottaviano, Margaret
Rosanova, Mario
Silvestri, Antonia
Tufo, Andrea
Cozzolino, Antonio
Daniele, Bruno
CANCERS, 2020, 12 (10) : 1 - 20
[35] Radiation and Immune Checkpoint Inhibitors: Combination Therapy for Treatment of Hepatocellular Carcinoma
Chami, Perla
Diab, Youssef
Khalil, Danny N.
Azhari, Hassan
Jarnagin, William R.
Abou-Alfa, Ghassan K.
Harding, James J.
Hajj, Joseph
Ma, Jennifer
El Homsi, Maria
Reyngold, Marsha
Crane, Christopher
Hajj, Carla
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (23)
[36] Challenges and Opportunities in the Clinical Development of Immune Checkpoint Inhibitors for Hepatocellular Carcinoma
Flynn, Michael J.
Sayed, Anwar A.
Sharma, Rohini
Siddique, Abdul
Pinato, David J.
HEPATOLOGY, 2019, 69 (05) : 2258 - 2270
[37] Combination Therapy of Immune Checkpoint Inhibitors with Locoregional Therapy for Hepatocellular Carcinoma
Tamai, Yasuyuki
Fujiwara, Naoto
Tanaka, Takamitsu
Mizuno, Shugo
Nakagawa, Hayato
CANCERS, 2023, 15 (20)
[38] Which role for predictors of response to immune checkpoint inhibitors in hepatocellular carcinoma?
Rizzo, Alessandro
Cusmai, Antonio
Gadaleta-Caldarola, Gennaro
Palmiotti, Gennaro
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY, 2022, 16 (04) : 333 - 339
[39] Immune Phenotype and Immune Checkpoint Inhibitors for the Treatment of Human Hepatocellular Carcinoma
Nishida, Naoshi
Kudo, Masatoshi
CANCERS, 2020, 12 (05)
[40] Immune Checkpoint Inhibitors as Therapy to Down-Stage Hepatocellular Carcinoma Prior to Liver Transplantation
Katariya, Nitin N.
Lizaola-Mayo, Blanca C.
Chascsa, David M.
Giorgakis, Emmanouil
Aqel, Bashar A.
Moss, Adyr A.
Uson Junior, Pedro Luiz Serrano
Borad, Mitesh J.
Mathur, Amit K.
CANCERS, 2022, 14 (09)

← 1 2 3 4 5 →