Metabolomic signatures associated with fetal growth restriction and small for gestational age: a systematic review

被引:2
作者
Conde-Agudelo, Agustin [1 ]
Villar, Jose [1 ,2 ]
Risso, Milagros [3 ]
Papageorghiou, Aris T. [1 ,2 ]
Roberts, Lee D. [4 ]
Kennedy, Stephen H. [1 ,2 ]
机构
[1] Univ Oxford, Oxford Maternal & Perinatal Hlth Inst, Green Templeton Coll, Oxford, England
[2] Univ Oxford, Nuffield Dept Womens & Reprod Hlth, Oxford, England
[3] Hosp Univ Gen Villalba, Madrid, Spain
[4] Univ Leeds, Leeds Inst Cardiovasc & Metab Med, Leeds, England
基金
比尔及梅琳达.盖茨基金会;
关键词
CORD BLOOD; POSTABSORPTIVE RATS; QUALITY ASSESSMENT; PROTEIN-SYNTHESIS; SKELETAL-MUSCLE; AMINO-ACIDS; PRETERM; BIOMARKERS; BIRTH; RISK;
D O I
10.1038/s41467-024-53597-4
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The pathways involved in the pathophysiology of fetal growth restriction (FGR) and small for gestational age (SGA) are incompletely understood. We conduct a systematic review to identify metabolomic signatures in maternal and newborn tissues and body fluids samples associated with FGR/SGA. Here, we report that 825 non-duplicated metabolites were significantly altered across the 48 included studies using 10 different human biological samples, of which only 56 (17 amino acids, 12 acylcarnitines, 11 glycerophosphocholines, six fatty acids, two hydroxy acids, and eight other metabolites) were significantly and consistently up- or down-regulated in more than one study. Three amino acid metabolism-related pathways and one related with lipid metabolism are significantly associated with FGR and/or SGA: biosynthesis of unsaturated fatty acids in umbilical cord blood, and phenylalanine, tyrosine and tryptophan biosynthesis, valine, leucine and isoleucine biosynthesis, and phenylalanine metabolism in newborn dried blood spot. Significantly enriched metabolic pathways were not identified in the remaining biological samples. Whether these metabolites are in the causal pathways or are biomarkers of fetal nutritional deficiency needs to be explored in large, well-phenotyped cohorts. Fetal growth restriction remains a global health problem. In this systematic review, the authors identify altered metabolites and metabolomic signatures associated with fetal growth restriction and/or small for gestational age in maternal and newborn tissues and body fluids samples.
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页数:22
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