Applications of liposomes and lipid nanoparticles in cancer therapy: current advances and prospects

被引：10

作者：

Cheng, Zhe ^{[1
]}

Huang, Huichao ^{[2
,3
]}

Yin, Meilong ^{[1
]}

Liu, Huaizheng ^{[1
]}

机构：

[1] Cent South Univ, Xiangya Hosp 3, Dept Emergency, Changsha 410013, Peoples R China

[2] Cent South Univ, Xiangya Hosp, Dept Oncol, NHC Key Lab Canc Prote,Lab Struct Biol, Changsha 410008, Peoples R China

[3] Cent South Univ, Xiangya Hosp, Dept Infect Dis, Changsha 410008, Peoples R China

来源：

EXPERIMENTAL HEMATOLOGY & ONCOLOGY | 2025年 / 14卷 / 01期

关键词：

Liposome; Lipid nanoparticle; Cancer therapy; Targeted delivery; TME; Tumor vaccination; DRUG-DELIVERY SYSTEMS; PROTEIN CORONA; BREAST-CANCER; GENE-THERAPY; CO-DELIVERY; IN-VITRO; THERMOSENSITIVE LIPOSOMES; REGULATORY CONSIDERATIONS; RESPONSIVE LIPOSOMES; TRANSFERRIN RECEPTOR;

D O I：

10.1186/s40164-025-00602-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Liposomes and lipid nanoparticles are common lipid-based drug delivery systems and play important roles in cancer treatment and vaccine manufacture. Although significant progress has been made with these lipid-based nanocarriers in recent years, efficient clinical translation of active targeted liposomal nanocarriers remains extremely challenging. In this review, we focus on targeted liposomes, stimuli-responsive strategy and combined therapy in cancer treatment. We also summarize advances of liposome and lipid nanoparticle applications in nucleic acid delivery and tumor vaccination. In addition, we discuss limitations and challenges in the clinical translation of these lipid nanomaterials and make recommendations for the future research in cancer therapy.

引用

页数：21

共 50 条

[21] Lipid-based Nanoplatforms in Cancer Therapy: Recent Advances and Applications [J].

Rajpoot, Kuldeep .

CURRENT CANCER DRUG TARGETS, 2020, 20 (04) :271-287

[22] Current state and prospects of the phytosynthesized colloidal gold nanoparticles and their applications in cancer theranostics [J].

Ovais, Muhammad ;

Raza, Abida ;

Naz, Shagufta ;

Ul Islam, Nazar ;

Khalil, Ali Talha ;

Ali, Shaukat ;

Khan, Muhammad Adeeb ;

Shinwari, Zabta Khan .

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2017, 101 (09) :3551-3565

[23] Recent advances in liposome-based targeted cancer therapy [J].

Fidan, Yeliz ;

Mucaj, Stela ;

Timur, Selin Seda ;

Gursoy, R. Neslihan .

JOURNAL OF LIPOSOME RESEARCH, 2024, 34 (02) :316-334

[24] Current Advances in Aptamers for Cancer Diagnosis and Therapy [J].

Hori, Shin-ichiro ;

Herrera, Alberto ;

Rossi, John J. ;

Zhou, Jiehua .

CANCERS, 2018, 10 (01)

[25] Mesoporous silica nanoparticles for breast cancer theranostics: advances in imaging and therapy [J].

Pires, Indira C. B. ;

Filho, Idio A. S. ;

Nunes, Celina T. T. ;

Junior, Severino A. ;

Mathis, J. Michael .

JOURNAL OF NANOPARTICLE RESEARCH, 2025, 27 (07)

[26] A Review of Different Types of Liposomes and Their Advancements as a Form of Gene Therapy Treatment for Breast Cancer [J].

Tseu, Gloria Yi Wei ;

Kamaruzaman, Khairul Azfar .

MOLECULES, 2023, 28 (03)

[27] Current Advances in Small Acivating RNAs for Gene Therapy: Principles, Applications and Challenges [J].

Zhou, Ling-Yan ;

He, Zhi-Yao ;

Xu, Ting ;

Wei, Yu-Quan .

CURRENT GENE THERAPY, 2018, 18 (03) :134-142

[28] Optical spectroscopy: current advances and future applications in cancer diagnostics and therapy [J].

Evers, D. J. ;

Hendriks, B. H. W. ;

Lucassen, G. W. ;

Ruers, T. J. M. .

FUTURE ONCOLOGY, 2012, 8 (03) :307-320

[29] Nanostructured lipid carriers in cancer therapy: Advances in passive and active targeting strategies [J].

Alkhamach, Dana ;

Khan, Saeed Ahmad ;

Greish, Khaled ;

Hassan, Hatem A. F. M. ;

Haider, Mohamed .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2025, 678

[30] Surface-functionalised polymeric nanoparticles for breast cancer treatment: processes and advances [J].

Prasad, Aprameya ;

Bakr, Mohamed Mofreh ;

Elmeshad, Aliaa N. .

JOURNAL OF DRUG TARGETING, 2024, 32 (07) :770-784

← 1 2 3 4 5 →