FLASH radiotherapy: mechanisms, nanotherapeutic strategy and future development

被引：0
作者：
Wang, Yan [1 ]
Wang, Huifang [1 ]
Hu, Jiawei [1 ]
Chai, Jingjing [1 ]
Luan, Jiajie [1 ]
Li, Jie [2 ]
Xu, Qingwen [1 ]
机构：
[1] Wannan Med Coll, Yijishan Hosp, Dept Pharm, Affiliated Hosp 1, Wuhu, Peoples R China
[2] Univ Elect Sci & Technol China, Mianyang Cent Hosp, Sch Med, Mianyang, Peoples R China
来源：
NANOSCALE ADVANCES | 2025年 / 7卷 / 03期
关键词：
RADIATION-THERAPY; DOSE-RATES; IRRADIATION; CANCER; LUNG; CARCINOMA; CELLS; VIVO;
D O I：
10.1039/d4na00753k
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Ultra-high dose-rate (FLASH) radiotherapy serves as an ideal procedure to treat tumors efficiently without harming normal tissues and has demonstrated satisfactory antitumor effects in multiple animal tumor models. However, the biological mechanisms of FLASH radiotherapy have not yet been fully elucidated, and the small number of devices delivering FLASH dose rate has limited its wide application. This review summarizes the possible biological mechanisms and antitumor effects of FLASH radiotherapy, its application in nanotherapeutic strategy, as well as its challenges and future development. Furthermore, some valuable guidance for promoting the progress of FLASH radiotherapy in nanotherapeutic strategies are provided.
引用
收藏
页码：711 / 721
页数：11
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