Causal relationship between psoriasis and sudden deafness: a Mendelian randomization study

Objective This study aims to investigate the genetic link between psoriasis and sudden sensorineural hearing loss (SSNHL). Methods From a genetic standpoint, this study further highlighted the connection between psoriasis and SSNHL. Single nucleotide polymorphisms (SNPs) connected to SSNHL could be found using a genome-wide association study from the IEU OpenGWAS project website. In addition, the inverse variance weighted (IVW) technique was used to evaluate the connection between psoriasis and SSNHL. Results According to Mendelian randomization analysis, IVW supported the causal relationship between psoriasis and SSNHL (OR = 808.86, 95%CI 3.32 similar to 196942.07, P = 0.02). In the sensitivity analysis, there was no heterogeneity or horizontal pleiotropy, and the Leave-one-out analysis suggested that the causal effect was robust.The results of MR-Egger (Q = 13.53, P = 0.76) and IVW (Q = 14.73, P = 0.74) showed that there was no heterogeneity in SNPs, and the results were reliable. We also performed a horizontal pleiotropic analysis (P = 0.29), which showed that there was no horizontal pleiotropy and no confounding factors in the study. Conclusion From a genetic perspective, there is a causal relationship between psoriasis and an increased risk of sudden sensorineural hearing loss.