Human dental pulp stem cells for spinal cord injury

被引：0
作者：
Kaizhong Wang [1 ]
Xiangyan Liu [2 ]
Xukai Jiang [1 ]
Shuang Chen [2 ]
Hui Wang [1 ]
Zhenbo Wang [2 ]
Qiwen Wang [1 ]
Zhonghai Li [2 ]
机构：
[1] Department of Orthopedics, First Affiliated Hospital of Dalian Medical University, Liaoning Province, Dalian
[2] Key Laboratory of Molecular Mechanism for Repair and Remodeling of Orthopedic Diseases, Liaoning Province, Dalian
[3] Dalian Innovation Institute of Stem Cell and Precision Medicine, Liaoning Province, Dalian
来源：
Stem Cell Research & Therapy | / 16卷 / 1期
关键词：
Apoptosis; Axonal regeneration; Dental pulp stem cells; Inflammatory; Neurorestoration; Spinal cord injury; Stem cells;
D O I：
10.1186/s13287-025-04244-2
中图分类号：
学科分类号：
摘要：
Spinal cord injury (SCI) is a serious neurological disorder that causes loss of mobility, pain, and autonomic dysfunction, resulting in altered sensation and devastating loss of function. Current treatments for SCI mainly focus on surgery and drug therapy to promote neurological recovery. However, there are virtually no effective remedies for irreversible nerve damage that result in a victim’s loss of motor function and sensory changes that occur after an injury. With the continuous development of medical technology, stem-cell-based regenerative medicine provides researchers with new treatment ideas. The effectiveness of mesenchymal stem cells and their derivatives from different sources in treating SCI varies. Recent studies have highlighted that dental pulp stem cells (DPSCs) may contribute to anti-inflammatory regulation, anti-apoptotic regulation, and axonal regeneration in the treatment of SCI patients. In addition, the combination of new biomaterials and dental pulp stem cells is promising in the treatment of SCI. This article reviews the role of DPSCs in SCI treatment in recent years, discusses the advantages of DPSCs, explores potential development directions, and looks forward to providing new insights for future research in this critical field. © The Author(s) 2025.
引用
收藏
相关论文
共 100 条
  • [1] Zipser C.M., Et al., Cell-based and stem-cell-based treatments for spinal cord injury: evidence from clinical trials, Lancet Neurol, 21, 7, pp. 659-670, (2022)
  • [2] Merritt C.H., Et al., Economic impact of traumatic spinal cord injuries in the United States, Neuroimmunol Neuroinflamm, 6, (2019)
  • [3] Global, regional, and National burden of spinal cord injury, 1990–2019: a systematic analysis for the global burden of disease study 2019, Lancet Neurol, 22, 11, pp. 1026-1047, (2023)
  • [4] Uchida S., Et al., Treatment of spinal cord injury by an advanced cell transplantation technology using brain-derived neurotrophic factor-transfected mesenchymal stem cell spheroids, Biomaterials, 109, pp. 1-11, (2016)
  • [5] Ahuja C.S., Et al., Traumatic spinal cord Injury-Repair and regeneration, Neurosurgery, 80, 3s, pp. S9-S22, (2017)
  • [6] Abbaszadeh F., Et al., The Role of Vitamins in Spinal Cord Injury: Mechanisms and Benefits, Oxid Med Cell Longev, 2024, (2024)
  • [7] Fehlings M.G., Et al., Early versus delayed decompression for traumatic cervical spinal cord injury: results of the surgical timing in acute spinal cord injury study (STASCIS), PLoS ONE, 7, 2, (2012)
  • [8] Adegeest C.Y., Ter Wengel P.V., Peul W.C., Traumatic spinal cord injury: acute phase treatment in critical care, Curr Opin Crit Care, 29, 6, pp. 659-665, (2023)
  • [9] Zlotolow D.A., Lipa B., Pahys J.M., Team approach: treatment and rehabilitation of patients with spinal cord injury resulting in tetraplegia, JBJS Rev, 7, 4, (2019)
  • [10] Zhou H., Et al., MSC based gene delivery methods and strategies improve the therapeutic efficacy of neurological diseases, Bioact Mater, 23, pp. 409-437, (2023)
12345678910