Sensori- and psychomotor abnormalities, psychopathological symptoms and functionality in schizophrenia-spectrum disorders: a network analytic approach

被引：0
作者：
Fritze, Stefan [1 ]
Brandt, Geva A. [1 ]
Volkmer, Sebastian [1 ,2 ]
Daub, Jonas [1 ]
Altinok, Dilsa Cemre Akkoc [1 ]
Kubera, Katharina M. [3 ]
Correll, Christoph U. [4 ,5 ,6 ,7 ]
Northoff, Georg [8 ]
Meyer-Lindenberg, Andreas [1 ,9 ]
Hirjak, Dusan [1 ,9 ]
机构：
[1] Heidelberg Univ, Cent Inst Mental Hlth, Med Fac Mannheim, Dept Psychiat & Psychotherapy, Mannheim, Germany
[2] Heidelberg Univ, Hector Inst Artificial Intelligence Psychiat, Cent Inst Mental Hlth, Med Fac Mannheim, Mannheim, Germany
[3] Heidelberg Univ, Ctr Psychosocial Med, Dept Gen Psychiat, Heidelberg, Germany
[4] German Ctr Mental Hlth DZPG, Partner Site Berlin, Berlin, Germany
[5] Charite Univ Med Berlin, Dept Child & Adolescent Psychiat, Berlin, Germany
[6] Northwell Hlth, Zucker Hillside Hosp, Dept Psychiat, Glen Oaks, NY USA
[7] Donald & Barbara Zucker Sch Med Hofstra Northwell, Dept Psychiat & Mol Med, Hempstead, NY USA
[8] Univ Ottawa, Royals Inst Mental Hlth Res, Mind Brain Imaging & Neuroeth Res Unit, Ottawa, ON, Canada
[9] German Ctr Mental Hlth DZPG, Partner Site Mannheim Heidelberg Ulm, Mannheim, Germany
来源：
SCHIZOPHRENIA | 2025年 / 11卷 / 01期
关键词：
NEUROLOGICAL SOFT SIGNS; INDUCED MOVEMENT-DISORDERS; NEGATIVE SYNDROME SCALE; 1ST-EPISODE SCHIZOPHRENIA; TARDIVE-DYSKINESIA; RESEARCH DOMAIN; RATING-SCALE; PREVALENCE; AKATHISIA; CATATONIA;
D O I：
10.1038/s41537-024-00547-0
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
Sensori- and psychomotor abnormalities are an inherent part of schizophrenia-spectrum disorders (SSD) pathophysiology and linked to psychopathological symptoms as well as cognitive and global functioning. However, how these different symptom clusters simultaneously interact with each other is still unclear. Here, we examined 192 SSD patients (37.75 +/- 12.15 years, 73 females). First, we investigated the cross-sectional prevalence and overlap of individual sensori- and psychomotor abnormalities. Second, we applied network analysis methods to simultaneously model the associations between Neurological Soft Signs (NSS), level of akathisia, parkinsonism symptoms, tardive dyskinesia (TD) and catatonia signs as well as cognition, psychopathology, global functioning and daily antipsychotic dose. The largest centralities were exhibited by NSS (0.90), catatonia signs (0.82) and global functioning (0.79). NSS showed strong partial correlations with cognition and parkinsonism symptoms (edge weight, ew = 0.409 and ew = 0.318, respectively). Catatonia signs showed strong connections with global functioning (ew = 0.333). In contrast, TD, akathisia and daily antipsychotic dose were weakly connected with other variables (e.g., largest ew=0.176 between TD and akathisia). In conclusion, NSS and cognition, parkinsonism symptoms and NSS as well as catatonia signs and global functioning seem to be preferentially connected in SSD. The daily medication had little influence on sensori- and psychomotor abnormalities, indicating that they are features of core SSD pathophysiology. Future studies should incorporate these relationships to enhance the understanding of SSD.
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页数：13
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