99mTc-radiolabeling study of 2-amino-3-(4-hydroxyphenyl)-1-hydroxypropyl-1,1-bisphosphonic acid as a potential bone imaging agent

被引：0

作者：

Hamouda, Walid ^{[1
]}

Abdel-Motaleb, Mohamed ^{[1
]}

El-Tawoosy, Mahmoud ^{[1
]}

Sanad, Mahmoud ^{[1
]}

Rizk, Sameh ^{[2
]}

El-Hashash, Maher ^{[2
]}

机构：

[1] Egyptian Atom Energy Author, Hot Labs Ctr, Labeled Cpds Dept, Cairo, Egypt

[2] Ain Shams Univ, Fac Sci, Cairo, Egypt

来源：

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY | 2025年 / 334卷 / 02期

关键词：

Bisphosphonates; Synthesis; Tc-99m; Radiolabeling; Radiopharmaceutical; Bone imaging; PHOSPHORUS TRICHLORIDE; BISPHOSPHONATES; BIODISTRIBUTION; NANOPARTICLES;

D O I：

10.1007/s10967-025-09984-2

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

2-Amino-3-(4-hydroxyphenyl)-1-hydroxypropyl-1,1-bisphosphonic acid (TyrBP), a nitrogenated bisphosphonate (NBP), has been synthesized in a one-pot two-step process involving the phosphonation of L-tyrosine with phosphorus reagents (PCl3 and H3PO3) followed by hydrolysis. TyrBP was characterized using IR, NMR, and mass spectroscopy, and underwent a( 99m)Tc-radiolabeling study to produce a potential bone imaging agent using sodium borohydride as a reducing agent for( 99m)Tc eluted from the Mo-99/Tc-99m generator. Optimization of the radiolabeling conditions was performed to achieve a high radiochemical yield.

引用

页码：1911 / 1918

页数：8

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