Association of peripheral neuropathy with dry eye disease and meibomian gland dysfunction in patients with type 1 diabetes

被引：0
作者：
Meryem Altin Ekin [1 ]
Hazan Gul Kahraman [2 ]
Emine Deniz Egrilmez [3 ]
Sehnaz Arici [4 ]
Guzide Gonca Oruk [5 ]
机构：
[1] Department of Ophthalmology, Dokuz Eylul University Faculty of Medicine, Izmir
[2] Department of Ophthalmology, Izmir Buca Seyfi Demirsoy Training and Research Hospital, Izmir
[3] Department of Ophthalmology, Izmir Katip Celebi University Ataturk Training and Research Hospital, Izmir
[4] Department of Neurology, Izmir Katip Celebi University Ataturk Training and Research Hospital, Izmir
[5] Department of Endocrinology and Metabolism, Izmir Katip Celebi University Ataturk Training and Research Hospital, Izmir
来源：
International Ophthalmology | / 45卷 / 1期
关键词：
Diabetes mellitus; Diabetic peripheral neuropathy; Dry eye; Meibomian gland; Ocular surface;
D O I：
10.1007/s10792-025-03420-w
中图分类号：
学科分类号：
摘要：
Purpose: To explore the relationship between dry eye disease and type 1 diabetes mellitus (DM) and also to identify whether diabetic peripheral neuropathy (DPN) was a significant predictor for the development of dry eye disease. Materials and methods: This prospective cross sectional study involved patients with type 1 DM and aged- and sex-matched healthy controls. All of the participants underwent dry eye tests including meibomian gland function. Based on neurologic examination and electromyography findings, diabetic patients were grouped as DPN + and DPN-. All findings were compared and predictive factors for dry eye disease were identified. Results: Of the 97 patients with type 1 DM, 42 (43.3%) were diagnosed as DPN. In patients with DM, there was a significant increase in the ocular surface disease index, corneal surface staining, eyelid margin abnormality and meibomian gland dysfunction and a significant decrease in tear break-up time and Schirmer’s I test (p < 0.05). Measurements of dry eye tests were more severe with the presence of DPN (p < 0.05). Age of the patients, duration of DM and HbA1c level were significantly correlated with ocular surface and meibomian gland dysfunction parameters (p < 0.05). Age of the patients (p < 0.001), duration of DM (p = 0.001), HbA1c level (p = 0.036) and presence of DPN (p < 0.001) were found to be the independent and significant predictors of dry eye disease. Conclusion: Type 1 DM was found to be significantly associated with ocular surface abnormalities including meibomian gland dysfunction. Furthermore, age of the patients, duration of DM, HbA1c level and presence of DPN were predictive factors of dry eye disease in type 1 DM. © The Author(s), under exclusive licence to Springer Nature B.V. 2025.
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  • [1] Forbes J.M., Cooper M.E., Mechanisms of diabetic complications, Physiol Rev, 93, 1, pp. 137-188, (2013)
  • [2] Ljubimov S.V., Diabetic complications in the cornea, Vision Res, 139, pp. 138-152, (2017)
  • [3] Braffett B.H., Gubitosi-Klug R.A., Albers J.W., Et al., Risk factors for diabetic peripheral neuropathy and cardiovascular autonomic neuropathy in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study, Diabetes, 69, 5, pp. 1000-1010, (2020)
  • [4] Achtsidis V., Eleftheriadou I., Kozanidou E., Et al., Dry eye syndrome in subjects with diabetes and association with neuropathy, Diabetes Care, 37, 10, pp. e210-e211, (2014)
  • [5] DeMill D.L., Hussain M., Pop-Busui R., Et al., Ocular surface changes in patients with diabetic neuropathy, Br J Ophthalmol, 100, 7, pp. 924-928, (2016)
  • [6] Misra S.L., Patel D.V., McGhee C.N.J., Et al., Peripheral neuropathy and tear film dysfunction in type 1 diabetes mellitus, Diabetes Res, 2014, (2014)
  • [7] Najafi L., Malek M., Valojerdi A.E., Et al., Dry eye and its correlation to diabetes microvascular complications in people with type 2 diabetes mellitus, J Diabetes Complic, 27, 5, pp. 459-462, (2013)
  • [8] Dogru M., Katakami C., Inoue M., Tear function and ocular surface changes in noninsulin-dependent diabetes mellitus, Ophthalmology, 108, 3, pp. 586-592, (2001)
  • [9] Cousen P., Cackett P., Bennett H., Et al., Tear production and corneal sensitivity in diabetes, J Diabetes Complic, 21, 6, pp. 371-373, (2007)
  • [10] Miyata K., Amano S., Sawa M., Et al., A novel grading method for superficial punctate keratopathy magnitude and its correlation with corneal epithelial permeability, Arch Ophthalmol, 121, pp. 1537-1539, (2003)
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