Intratumoral microbiome: implications for immune modulation and innovative therapeutic strategies in cancer

被引：3

作者：

Wang, Na ^{[1
,2
]}

Wu, Si ^{[1
,2
]}

Huang, Lanxiang ^{[1
,2
]}

Hu, Yue ^{[1
,2
]}

He, Xin ^{[1
,2
]}

He, Jourong ^{[1
,2
]}

Hu, Ben ^{[3
]}

Xu, Yaqi ^{[1
,2
]}

Rong, Yuan ^{[1
,2
]}

Yuan, Chunhui ^{[4
]}

Zeng, Xiantao ^{[5
,6
]}

Wang, Fubing ^{[1
,2
,7
]}

机构：

[1] Wuhan Univ, Zhongnan Hosp, Dept Lab Med, Wuhan 430071, Peoples R China

[2] Wuhan Univ, Zhongnan Hosp, Ctr Single Cell Om & Tumor Liquid Biopsy, Wuhan 430071, Peoples R China

[3] Wuhan Univ, Hubei Engn Res Ctr, Tumor Precis Diag & Treatment Technol & Translat, Zhongnan Hosp, Wuhan 430071, Peoples R China

[4] Huazhong Univ Sci & Technol, Wuhan Childrens Hosp, Wuhan Maternal & Child Healthcare Hosp, Tongji Med Coll,Dept Lab Med, Wuhan 430016, Peoples R China

[5] Wuhan Univ, Ctr Evidence Based & Translat Med, Zhongnan Hosp, Wuhan 430071, Peoples R China

[6] Wuhan Univ, Zhongnan Hosp, Dept Urol, Wuhan 430071, Peoples R China

[7] Chinese Acad Med Sci, Wuhan Res Ctr Infect Dis & Canc, Wuhan 430071, Peoples R China

来源：

JOURNAL OF BIOMEDICAL SCIENCE | 2025年 / 32卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Intratumoral microbiome; Omics technology; Immunomodulation; Microbiome-immune crosstalk; Immunotherapy; Therapeutic interventions; PRE-METASTATIC NICHE; FUSOBACTERIUM-NUCLEATUM; TUMOR MICROBIOME; BREAST-CANCER; COLORECTAL CARCINOGENESIS; HOST-DEFENSE; CELLS; MACROPHAGES; TISSUE; TUMORIGENESIS;

D O I：

10.1186/s12929-025-01117-x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recent advancements have revealed the presence of a microbiome within tumor tissues, underscoring the crucial role of the tumor microbiome in the tumor ecosystem. This review delves into the characteristics of the intratumoral microbiome, underscoring its dual role in modulating immune responses and its potential to both suppress and promote tumor growth. We examine state-of-the-art techniques for detecting and analyzing intratumoral bacteria, with a particular focus on their interactions with the immune system and the resulting implications for cancer prognosis and treatment. By elucidating the intricate crosstalk between the intratumoral microbiome and the host immune system, we aim to uncover novel therapeutic strategies that enhance the efficacy of cancer treatments. Additionally, this review addresses the existing challenges and future prospects within this burgeoning field, advocating for the integration of microbiome research into comprehensive cancer therapy frameworks.

引用

页数：26