Synthesis and Analgesic Activity of Ureas and Imidazolidine-2,4,5-trione Derivatives Containing Adamantane and Monoterpene Fragments

被引：0

作者：

Rogozin, P. E. ^{[1
]}

Suslov, E. V. ^{[1
]}

Filippova, A. Yu. ^{[1
]}

Pavlova, A. V. ^{[1
]}

Volcho, K. P. ^{[1
]}

Salakhutdinov, N. F. ^{[1
]}

机构：

[1] Russian Acad Sci, NN Vorozhtsov Novosibirsk Inst Organ Chem, Siberian Branch, Novosibirsk 630090, Russia

来源：

RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2025年 / 95卷 / 01期

基金：

俄罗斯科学基金会;

关键词：

adamantane; monoterpenes; analgesic activity;

D O I：

10.1134/S1070363224612808

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

AbstractA series of ureas and substituted parabanic acids containing monoterpene and adamantane fragments were synthesized. It was found that urea containing a (-)-menthone residue, as well as an imidazolidine-2,4,5-trione derivative with a (+)-campholenaldehyde moiety, exhibit analgesic activity.

引用

页码：23 / 29

页数：7

共 3 条

[1] Synthesis of Norabietyl and Nordehydroabietyl Imidazolidine-2,4,5-Triones and Their Activity against Tyrosyl-DNA Phosphodiesterase 1
Kovaleva, Kseniya S.
Yarovaya, Olga I.
Chernyshova, Irina A.
Zakharenko, Alexandra L.
Cheresiz, Sergey V.
Azimirad, Amirhossein
Pokrovsky, Andrey G.
Lavrik, Olga I.
Salakhutdinov, Nariman F.
MOLBANK, 2023, 2023 (04)
[2] Synthesis and inhibitory activity of 1,3-(adamantan-1(2)-yl)- imidazolidine-2,4,5-triones and 3,3'-(adamantan-1-yl)- bis(1-alkylimidazolidine-2,4,5-triones)
D'yachenko, Vladimir S.
Burmistrov, Vladimir V.
Nishi, Kosuke
Kim, In-Hae
Butov, Gennady M.
CHEMISTRY OF HETEROCYCLIC COMPOUNDS, 2017, 53 (10) : 1080 - 1083
[3] Synthesis and inhibitory activity of 1,3-(adamantan-1(2)-yl)- imidazolidine-2,4,5-triones and 3,3'-(adamantan-1-yl)- bis(1-alkylimidazolidine-2,4,5-triones)
Vladimir S. D’yachenko
Vladimir V. Burmistrov
Kosuke Nishi
In-Hae Kim
Gennady M. Butov
Chemistry of Heterocyclic Compounds, 2017, 53 : 1080 - 1083

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