Elevated neuron specific enolase levels in post-traumatic stress disorder

Neuron-specific enolase (NSE) is a biomarker indicative of neuronal cell damage. The aim of this study is to assess the NSE levels in patients diagnosed with post-traumatic stress disorder (PTSD) and major depressive disorder (MDD). Blood samples were collected from 43 individuals with PTSD (age range 11-17), 43 individuals with MDD (age range 10-17), and 40 age- and gender-matched healthy controls. The NSE levels were analyzed, and participants completed the Post-traumatic Stress Reaction Index, the Children's Depression Inventory, and the Screen for Child Anxiety Related Disorders. Additionally, the Clinical Global Impressions Scale was filled out by the researcher. Results indicated that the NSE levels in the PTSD group were significantly higher than those in both the MDD group and the healthy control group. No significant difference in NSE levels was observed between the MDD group and the healthy control group.Conclusions: The findings suggest that elevated NSE levels in PTSD may be indicative of stress-related neuronal damage, distinguishing PTSD from MDD and healthy controls. These results underline the need for further research to explore the potential of NSE as a biomarker for PTSD and its implications for diagnosis and intervention strategies. What is Known:center dot Neuron-specific enolase (NSE) is a biomarker indicative of neuronal cell damage.center dot Elevated NSE levels have been observed in certain neuropsychiatric and neurological conditions, reflecting neuronal damage or stress.What is New:center dot NSE levels in adolescents with PTSD are significantly higher than those in both MDD patients and healthy controls, suggesting a specific association with trauma-related neuronal damage.center dot No significant difference in NSE levels was observed between MDD patients and healthy controls, highlighting the distinct neurobiological impact of trauma compared to depressive disorders.