A chemosensing approach for the detection of Cu2+ ion using benzothiazole based probe and its applications in anticancer studies

The current reseach work describes the design and synthesis of a novel chemodinace (2-(benzo[d]thycol-2-31)-5-(((4-bromophenyliminomethyl)phanol) (HBPA) for the detection of metal sops Formation of the probe (HBPA) swas confirmed by using various spectroscopic techniques. The senting ability of HBPA with vario metal int were examined mined by colorimetric and flustimetric techniques and the obtained results confirmed the selective detection of Cu ions by the probe with the limit of detection of 2.0300x10 M. The probe exhibi bited good binding constant with the Cu ion as 3.6957+0.3310 M Spectral rem revealed 1:2 stoiionary in the complex HBPA-Cu during interaction between metal and probe. Expe mental observatidis on binding of the probe with copper ions was corroborated with density functional theory (DFT). Further, the cytotoxic nanure of the probe and probe-Cu have been examined with Hala Juman cer vical cancer cells and HepG2 Chuman liver cancer cell) and the obtained results revealed that the compounds possessed good cxtotoxic activity compared with the positive control doxorubicin HBPA acts as a good che mosensor for the section of Cu ion as well as exhibits good eytonxic activity towards the HepG2 and Hea cell lines