Hormone replacement therapy for steatotic liver management after surgical menopause

被引：0

作者：

Kobayashi, Yoshiaki ^{[1
]}

Yamashita, Yuki ^{[1
,2
]}

Kimura, Takefumi ^{[1
,2
]}

Iwadare, Takanobu ^{[1
]}

Okumura, Taiki ^{[1
]}

Wakabayashi, Shun-ichi ^{[1
]}

Kobayashi, Hiroyuki ^{[1
]}

Sugiura, Ayumi ^{[1
]}

Joshita, Satoru ^{[1
]}

Umemura, Takeji ^{[1
,2
]}

机构：

[1] Shinshu Univ, Sch Med, Dept Med, Div Gastroenterol & Hepatol, 3-1-1 Asahi, Matsumoto, Nagano 3908621, Japan

[2] Shinshu Univ Hosp, Consultat Ctr Liver Dis, Matsumoto, Japan

来源：

CLINICAL JOURNAL OF GASTROENTEROLOGY | 2025年 / 18卷 / 02期

关键词：

Steatotic liver disease; Surgical menopause; Hormone replacement therapy; NONALCOHOLIC FATTY LIVER; POSTMENOPAUSAL WOMEN; RISK-FACTOR; DISEASE; FIBROSIS; ESTRADIOL; ACTIVATION; GENDER; HRT;

D O I：

10.1007/s12328-024-02090-y

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Although steatotic liver onset after natural menopause has been reported, evidence on the clinical course and treatment options for steatotic liver after surgical menopause is scarce. A 34-year-old woman with a history of severe obesity presented to our department with liver dysfunction following total hysterectomy and bilateral oophorectomy. Her serum estradiol level was notably low at 22 pg/mL, and a liver biopsy revealed significant fatty degeneration, lobular inflammation, hepatocyte ballooning, and stage F1 fibrosis. These findings supported a diagnosis of steatotic liver disease following surgical menopause. Subsequent initiation of hormone replacement therapy (HRT) with estrogen led to rapid improvements in liver function and steatotic liver symptoms. Steatotic liver disease should be considered in cases of liver impairment in postoperative menopausal patients, for which HRT represents a promising treatment option.

引用

页码：352 / 356

页数：5

共 35 条

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