Clinical significance of serum Helicobacter pylori antibody cytotoxin-associated gene A levels in patients with unstable angina

被引：0

作者：

Jia, Haizhen ^{[1
]}

Fan, Huajun ^{[2
]}

Zhao, Jinhe ^{[1
]}

Peng, Jun ^{[1
]}

Pan, Yunhong ^{[1
]}

Peng, Hongyan ^{[3
]}

机构：

[1] Wuhan Univ Sci & Technol, Tianyou Hosp, Cardiovasc Dept, Wuhan 430064, Hubei, Peoples R China

[2] Wuhan Univ, Renmin Hosp, Dept Plast Surg, Wuhan 430060, Hubei, Peoples R China

[3] Taikang Tongji Wuhan Hosp, Dept Ultrasound Imaging, 322 North Sixin Rd, Wuhan 430050, Hubei, Peoples R China

来源：

EUROPEAN JOURNAL OF MEDICAL RESEARCH | 2024年 / 29卷 / 01期

关键词：

Helicobacter pylori; Cytotoxin-associated gene A; Unstable angina; SYNTAX; CAGA; GUIDELINES; DISEASE;

D O I：

10.1186/s40001-024-02208-5

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

ObjectivesWe investigated the clinical significance of serum Helicobacter pylori cytotoxin-associated gene A (CagA) antibody levels in 768 patients with unstable angina (UA).MethodsSerum CagA levels were measured using ELISA. Demographic data, serum biomarkers, and SYNTAX scores were collected. Patients were followed up for 1 year for major adverse cardiac events (MACE).ResultsCagA-positive UA patients had higher total cholesterol and hsCRP levels, and SYNTAX scores. CagA levels correlated positively with TC, hsCRP, and SYNTAX scores. Kaplan-Meier analysis showed shorter MACE-free survival in CagA-positive UA patients. CagA levels predicted MACE occurrence within 1 year, along with SYNTAX scores.ConclusionsSerum H. pylori CagA antibody positivity is associated with worse prognosis in UA patients. CagA levels correlate with lipid metabolism and inflammatory markers.

引用

页数：8

共 32 条

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