BackgroundMany psychological changes occur during adolescence, as well as, for some, behavioral disorders. Two such deviant behaviors are internet gaming disorder and oppositional defiant disorder. Prior research has documented the relationships between oppositional defiant disorder and internet gaming addiction with suicidal ideation among adolescents, but none has studied the potential mediating role of self-control nor the moderation role of gender. ObjectiveThis study investigated the relationships between oppositional defiant disorder, internet gaming disorder, and suicidal ideation, and applied a moderated mediation model including the roles of gender and self-control. Method273 adolescents (mean age = 15.47, 57% females) participated in the study. Respondents completed the Suicidal Ideation Scale; the Internet Gaming Disorder Scale, Short Form; the Oppositional Defiant Scale; and the Self-Control Scale; as well as a set of socio-demographic questions. A moderated mediation model was applied using the PROCESS software package. ResultsOppositional defiant disorder and internet addiction were positively related with suicidal ideation (beta = 0.89, p < 0.001 and beta = 0.31, p < 0.001, respectively). Self-control was found to mediate these relationships (beta ind = 0.10, CI = 0.03 to 0.18 for the oppositional defiant disorder -suicidal ideation relationship) and (beta ind = 0.19, CI = 0.12 to 0.26 for internet gaming disorder-suicidal ideation relationship). Further, it was found that these relationships were stronger in females compared to males. ConclusionsEfforts to reduce suicidal ideation among adolescents with defiant behaviors and gaming disorder should be directed at enhancing their self-control and should be gender mindful.