Increased FT3/FT4 ratio in a certain range is associated with decreased glycemic variability in patients with type 2 diabetes

被引：2

作者：

Li, Ying ^{[1
,2
]}

Pan, Tianrong ^{[1
]}

Wang, Lingyu ^{[3
]}

Wang, Yue ^{[1
]}

Gong, Yu ^{[4
]}

Wang, Guojuan ^{[5
]}

Zhang, Qianqian ^{[5
]}

机构：

[1] Anhui Med Univ, Dept Endocrinol & Metab, Affiliated Hosp 2, 678 Furong Rd, Hefei 230601, Anhui, Peoples R China

[2] Hefei City First Peoples Hosp, Hefei 230032, Anhui, Peoples R China

[3] USTC Anhui Prov Hosp, Dept Oncol, Affiliated Hosp 1, Hefei 230001, Anhui, Peoples R China

[4] Anhui Med Univ, Hefei City Peoples Hosp 1, Hefei 230001, Anhui, Peoples R China

[5] Hefei City First Peoples Hosp, Dept Endocrinol & Metab, Hefei, Anhui, Peoples R China

来源：

SCIENTIFIC REPORTS | 2024年 / 14卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Free triiodothyronine to free thyroxine (FT3/FT4) ratio; Glycemic variability; Type; 2; diabetes; Continuous glucose monitoring; THYROID-HORMONE; GLUCOSE; SENSITIVITY; MORTALITY; DISEASE; HEALTH; RISK;

D O I：

10.1038/s41598-024-76074-w

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Thyroid hormone (TH) plays a crucial role in regulating glucose metabolism. However, the potential impact of the FT3/FT4 ratio, which reflects peripheral sensitivity to thyroid hormones, on glycemic variability in patients with type 2 diabetes (T2DM), has not been previously reported. To investigate the correlation between the FT3/FT4 ratio and glycemic variability in individuals with T2DM. In this retrospective analysis, a total of 468 inpatients with T2DM underwent continuous glucose monitoring (CGM) systems for a period of 6-14 days. Baseline clinical characteristics, laboratory tests, and CGM parameters were documented to investigate the correlation between FT3/FT4 ratio and CGM parameters. The levels of HBA, MG, SD, CV, LAGE, MODD and TAR2Scale were all higher in FT3/FT4Q1 compared with FT3/FT4Q2, FT3/FT4Q3 and FT3/FT4Q4 (all P < 0.01). Additionally, TIR was lower in FT3/FT4Q1 compared with the other quartiles (P < 0.01). Smooth curve fitting and saturation effect analysis revealed that there are curve-like relationships between the FT3/FT4 ratio and SD, MAGE, MODD and TAR2Scale. The inflection points of the fitted curves were found to be at FT3/FT4 = 0.279, 0.237, 0.253 and 0.282 respectively (all P < 0.05). Prior to the inflection point, the FT3/FT4 ratio was negatively related to SD, MAGE, MODD and TAR2Scale (all P < 0.05). Furthermore, The FT3/FT4 ratio exhibits a negative linear correlation with HBA and MG, while demonstrating a positive linear relationship with TIR (all P < 0.05). Binary logistic regression demonstrated that the FT3/FT4 ratio was independently related to HBA (P = 0.001), MG (P = 0.01), TAR2Scale (P = 0.003), LAGE (P = 0.014) and MAGE (P < 0.001). The increased FT3/FT4 ratio within a certain range (FT3/FT4 <= 0.282) is associated with decreased blood glucose variability and increased TIR. The FT3/FT4 ratio may act as a potential independent protective factor for glycemic fluctuation and glycemic control in patients with T2DM when it increases within a specific range.

引用

页数：15

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