Timing of menarche and menopause and epigenetic aging among US adults: results from the National Health and Nutrition Examination Survey 1999-2002

被引：0

作者：

Daredia, Saher ^{[1
]}

Khodasevich, Dennis ^{[2
]}

Gladish, Nicole ^{[2
]}

Shen, Hanyang ^{[2
]}

Nwanaji-Enwerem, Jamaji C. ^{[3
,4
]}

Bozack, Anne K. ^{[2
]}

Needham, Belinda L. ^{[5
]}

Rehkopf, David H. ^{[2
,7
]}

Deardorff, Julianna ^{[6
]}

Cardenas, Andres ^{[2
,7
]}

机构：

[1] Univ Calif Berkeley, Sch Publ Hlth, Div Epidemiol, Berkeley, CA 94720 USA

[2] Stanford Univ, Sch Med, Dept Epidemiol & Populat Hlth, Stanford, CA 94305 USA

[3] Univ Penn, Perelman Sch Med, Dept Emergency Med, Philadelphia, PA USA

[4] Univ Penn, Perelman Sch Med, Ctr Excellence Environm Toxicol, Philadelphia, PA USA

[5] Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ctr Social Epidemiol & Populat Hlth, Ann Arbor, MI USA

[6] Univ Calif Berkeley, Sch Publ Hlth, Div Community Hlth Sci, Berkeley, CA 94720 USA

[7] Stanford Univ, Dept Pediat, Sch Med, Stanford, CA 94305 USA

来源：

CLINICAL EPIGENETICS | 2025年 / 17卷 / 01期

关键词：

Menarche; Menopause; DNA methylation; Epigenetic aging;

D O I：

10.1186/s13148-025-01827-x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Reproductive aging, including timing of menarche and menopause, influences long-term morbidity and mortality in women, yet underlying biological mechanisms remain poorly understood. Using DNA methylation-based biomarkers, we assessed associations of age at menarche (N = 1,033) and menopause (N = 658) with epigenetic aging in a nationally representative sample of women >= 50 years. Later age at menopause was associated with lower GrimAge epigenetic age deviation (B\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$B$$\end{document} = - 0.10 years, 95% CI: - 0.19, - 0.02). No associations were observed for menarche timing. This suggests a connection between earlier menopause and biological aging, with potential clinical implications for identifying those at high risk for age-related disease.

引用

页数：5

共 10 条

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[10] Nov 28], Available from:, (2024)

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