Effect of Candida albicans' supernatant on biofilm formation and virulence factors of Pseudomonas aeruginosa through las/rhl System

被引：0

作者：

Zhang, Ke ^{[1
]}

Huang, Yingying ^{[1
]}

Jiang, Yuting ^{[1
]}

Liu, Tangjuan ^{[1
]}

Kong, Jinliang ^{[1
]}

Cai, Shuangqi ^{[1
]}

Wen, Zhongwei ^{[1
]}

Chen, Yiqiang ^{[1
]}

机构：

[1] Guangxi Med Univ, Dept Pulm & Crit Care Med, Affiliated Hosp 1, 6 Shuangyong Rd, Nanning City 530021, Guangxi Zhuang, Peoples R China

来源：

BMC MICROBIOLOGY | 2025年 / 25卷 / 01期

关键词：

Pseudomonas aeruginosa; Candida albicans; las/rhl system; biofilm; virulence; RESPIRATORY-TRACT; COLONIZATION;

D O I：

10.1186/s12866-024-03604-x

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Pseudomonas aeruginosa (P. aeruginosa) and Candida albicans (C. albicans) are opportunistic pathogens whose mixed infections can exacerbate microbial dissemination and drug resistance, contributing to high mortality and morbidity rates among infected individuals. Few studies have explored the impact of C. albicans supernatant on P. aeruginosa, and the underlying mechanisms of such mixed infections remain unclear. In this study, we investigated the effects of C. albicans supernatant on biofilm formation and virulence factor activity in wild-type P. aeruginosa PAO1 and its quorum sensing-deficient mutants, Delta lasIrhlI and Delta lasRrhlR. Our results demonstrated that the biofilm formation capability and virulence were significantly higher in the PAO1 group compared to the Delta lasIrhlI and Delta lasRrhlR groups. Furthermore, exposure to C. albicans supernatant significantly enhanced both the biofilm formation and virulence of PAO1, whereas no significant changes were observed in the Delta lasIrhlI and Delta lasRrhlR mutants relative to their respective controls. These findings suggest that C. albicans supernatant may modulate P. aeruginosa biofilm formation and virulence via the las/rhl quorum sensing system.

引用

页数：8

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