Essential amino acids and branched-chain amino acids are associated with skeletal muscle and inflammatory parameters in older age

被引：0

作者：

Li, Ching Wah Donna ^{[1
]}

Herpich, Catrin ^{[1
]}

Hass, Ulrike ^{[2
]}

Kochlik, Bastian ^{[3
]}

Weber, Daniela ^{[4
]}

Grune, Tilman ^{[4
,5
,6
]}

Norman, Kristina ^{[1
,5
,6
,7
]}

机构：

[1] German Inst Human Nutr Potsdam Rehbrucke, Dept Nutr & Gerontol, D-14558 Nuthetal, Germany

[2] Univ Potsdam, Fac Hlth Sci Brandenburg, Dept Rehabil Med, D-14469 Brandenburg, Germany

[3] Fed Inst Risk Assessment, Dept Food Safety, D-10589 Berlin, Germany

[4] German Inst Human Nutr Potsdam Rehbrucke, Dept Mol Toxicol, D-14558 Nuthetal, Germany

[5] Univ Potsdam, Inst Nutr Sci, Potsdam, Germany

[6] German Ctr Cardiovasc Res DZHK, Partner Site Berlin, Berlin, Germany

[7] Charite Univ Med Berlin, Dept Geriatr & Med Gerontol, D-13347 Berlin, Germany

来源：

BIOGERONTOLOGY | 2025年 / 26卷 / 02期

关键词：

Aging; Muscle health; Amino acids; Inflammation; Sarcopenia; Metabolism; FAT-FREE MASS; OXIDATIVE STRESS; METABOLISM; AUTOPHAGY;

D O I：

10.1007/s10522-025-10206-1

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Aging is associated with a decline in muscle mass and function, increasing the risk of adverse health outcomes. Amino acid profiling has emerged as a potential tool for assessing skeletal muscle health. This study examines the associations between fasting plasma amino acids, muscle function, and inflammation in healthy older and young adults. Data from 131 participants (101 older adults, 71.5 +/- 4.9 years; 30 young adults, 25.5 +/- 3.9 years) were analyzed. Skeletal muscle mass was assessed using bioimpedance analysis, and hand grip strength was measured with a dynamometer. Plasma amino acids, kynurenine, and inflammatory markers (CRP, IL-6) were quantified using ultraperformance liquid chromatography with tandem mass spectrometry and commercial immunosorbent assays, respectively. Older adults exhibited lower levels of glutamic acid, isoleucine, leucine, phenylalanine, kynurenine, and kynurenine-to-tryptophan (KYN:TRP) ratio compared to younger individuals (all p<0.05). In older adults, branched-chain and essential amino acids correlated positively with skeletal muscle index (SMI) and hand grip strength, whereas in young adults, only glutamic acid, proline, and KYN:TRP showed positive associations with SMI (all p<0.05). CRP and IL-6 were associated with several amino acids in older adults but not in younger individuals. These findings suggest that age-related shifts in amino acid profiles may reflect underlying changes in muscle metabolism and function, highlighting their potential as early indicators of muscle decline.

引用

页数：10

共 55 条

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