Evaluation of radiochemical yield and quality in automated [18F]fluorocholine synthesis with a modified GE TracerLab MX module

被引：0

作者：

Md. Jashim Uddin ^{[1
]}

Yun-Sang Lee ^{[2
]}

Yong-Hyun Cho ^{[1
]}

M. Anwar-Ul-Azim ^{[1
]}

Salma Khanom ^{[2
]}

机构：

[1] Seoul National University College of Medicine,Department of Nuclear Medicine

[2] Bangladesh Atomic Energy Commission,In

[3] Atomic Energy Research Establishment,Vitro and Radiochemistry Division, National Institute of Nuclear Medicine and Allied Science

来源：

Journal of Radioanalytical and Nuclear Chemistry | 2025年 / 334卷 / 1期

关键词：

Choline; 2-Deoxy-2-[; F]fluoro-; -glucose; Automated; Radiosynthesis; Positron emission tomography; [; F]fluoride;

D O I：

10.1007/s10967-024-09846-3

中图分类号：

学科分类号：

摘要：

[18F]fluorocholine ([18F]FCH) is an effective tracer for the imaging of different tumors of human brain, lung, or prostate. The purpose of this study was to evaluate the radiochemical yield and quality of routinely synthesized [18F]FCH by a modified 2-deoxy-2-[18F]fluoro-d-glucose ([18F]FDG) synthesizer (GE TracerLab MX). The radiosynthesis of [18F]FCH was completed in two steps taking 49 min. First, [18F]fluorobromomethane ([18F]FCH2Br) was synthesized from [18F]fluoride and dibromethane. Then, [18F]FCH as bromide salt was produced by N-alkylation of N,N-dimethylaminoethanol (DMAE) with [18F]fluorobromomethane. [18F]FCH had > 99.99% radiochemical purity, with non-decay-corrected and decay-corrected yields of 12(± 3)% and 16(± 4)%, respectively (n = 8).

引用

页码：293 / 302

页数：9