In this study, the effect of particle shape on dynamic characteristics and density-induced segregation behaviors was investigated in quasi-two-dimensional rotating drums. The experimental results indicate that, as the rotation speed increases, the final steady-state segregation index decreases, while the average velocity, average granular temperature, and dynamic repose angle increase. Furthermore, when the filling level decreases, the granular flowing layer becomes thinner, resulting in a decrease in the final steady-state segregation index. The results demonstrate that particle shape has significant influences on density-induced granular segregation behavior and dynamic properties. When the granular system combines the effects of shape and density, the final steady-state segregation intensity no longer increases monotonically with the density ratio. The dynamic repose angle increases as cube-shaped particles are added to the granular mixture. Additionally, cube-shaped particles sink easily due to poor flowability, which influences the granular temperature in the binary granular mixture.