Long-Term Changes in Parameters of Bone Quality in Kidney Transplant Recipients Treated with DenosumabLong-Term Changes in Parameters of Bone Quality in Kidney Transplant Recipients Treated…F. Pollastri et al

被引：0

作者：

Francesco Pollastri ^{[1
]}

Angelo Fassio ^{[1
]}

Pietro Manuel Ferraro ^{[2
]}

Stefano Andreola ^{[2
]}

Giovanni Gambaro ^{[2
]}

Andrea Spasiano ^{[2
]}

Chiara Caletti ^{[2
]}

Lisa Stefani ^{[2
]}

Matteo Gatti ^{[3
]}

Paolo Fabbrini ^{[3
]}

Maurizio Rossini ^{[1
]}

Isotta Galvagni ^{[1
]}

Davide Gatti ^{[1
]}

Giovanni Adami ^{[1
]}

Ombretta Viapiana ^{[1
]}

机构：

[1] University of Verona,Rheumatology Unit

[2] University of Verona,Nephrology Unit

[3] Department of Nephrology and Dialysis,undefined

来源：

Calcified Tissue International | / 116卷 / 1期

关键词：

Kidney transplant recipients; Denosumab; Indices of bone quality; DXA; TBS; 3D-DXA;

D O I：

10.1007/s00223-025-01349-x

中图分类号：

学科分类号：

摘要：

Kidney transplant recipients (KTRs) have an elevated fracture risk. While dual-energy X-ray absorptiometry (DXA) is commonly used to assess areal bone mineral density (aBMD), it does not capture all aspects of bone quality. We investigated the long-term effects on bone DXA-derived indices of bone quality in KTRs treated with denosumab and untreated with denosumab. This is a retrospective study, including KTRs treated with denosumab and untreated age and sex-matched KTR controls. DXA-derived parameters, including trabecular bone score (TBS) and 3D-DXA parameters, were measured at the lumbar spine and femur at baseline and after four years. Hierarchical linear models were used to assess the between-group effect of treatment over time, also adjusting for site-specific aBMDs. We enrolled 23 KTRs treated with denosumab and 23 KTR denosumab-untreated KTRs. Significant between-group differences over time in favor of the denosumab group were observed for TBS (0.843, 95%CI 0.439; 1.248,p < 0.001), trabecular volumetric BMD at the total hip (Tb.vBMD TH) (13.492, 95%CI 1.707; 25.278, p = 0.003), cortical volumetric BMD at the femoral neck (Ct.vBMD FN) (28.766, 95%CI 8.373; 49.158, p = 0.008), cortical surface BMD at the total hip (c.sBMD TH) (10.507, 95%CI 4.140; 16.873,p = 0.002), cortical surface at the femoral neck (c.sBMD FN) (8.795, 95%CI 2.818; 14.771, p = 0.006), and cortical thickness at the total hip (Ct.th.TH) (0.075, 95%CI 0.020; 0.130, p = 0.010). After adjusting for BMD, the differences on TBS and Ct.vBMD FN and c.sBMD FN remained significant. Denosumab treatment in KTRs was associated with better outcomes in terms of bone quality and geometry parameters, independent of changes in aBMD.

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