Targeted metabolomic profiling of acute ST-segment elevation myocardial infarction

被引：1

作者：

Markin, Sergey S. ^{[1
]}

Ponomarenko, E. A. ^{[1
]}

Romashova, Yu. A. ^{[1
]}

Pleshakova, T. O. ^{[1
]}

Ivanov, S. V. ^{[1
]}

Beregovykh, V. V. ^{[1
]}

Konstantinov, S. L. ^{[2
]}

Stryabkova, G. I. ^{[2
]}

Chefranova, Zh. Yu. ^{[3
]}

Lykov, Y. A. ^{[3
]}

Karamova, I. M. ^{[4
]}

Koledinskii, A. G. ^{[5
]}

Shestakova, K. M. ^{[6
]}

Markin, P. A. ^{[6
]}

Moskaleva, N. E. ^{[6
]}

Appolonova, S. A. ^{[6
,7
]}

机构：

[1] Inst Biomed Chem, Moscow 119121, Russia

[2] Belgorod Reg Clin Hosp St Joseph, Belgorod 308007, Russia

[3] Belgorod State Natl Res Univ, Belgorod 308015, Russia

[4] Ufa Emergency City Clin Hosp, Ufa 450092, Russia

[5] Peoples Friendship Univ Russia, Moscow 117198, Russia

[6] IM Sechenov First Moscow State Med Univ, Sechenov Univ, Inst Translat Med & Biotechnol, Lab Pharmacokinet & Metabol Anal, Moscow 119435, Russia

[7] IM Sechenov First Moscow State Med Univ, Sechenov Univ, Moscow 119435, Russia

来源：

SCIENTIFIC REPORTS | 2024年 / 14卷 / 01期

关键词：

Metabolomic profiling; Metabolic pathways; STEMI pathogenesis; CARDIOVASCULAR-DISEASE; CYTOSCAPE; METSCAPE; RISK;

D O I：

10.1038/s41598-024-75635-3

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Myocardial infarction is a major cause of morbidity and mortality worldwide. Metabolomic investigations may be useful for understanding the pathogenesis of ST-segment elevation myocardial infarction (STEMI). STEMI patients were comprehensively examined via targeted metabolomic profiling, machine learning and weighted correlation network analysis. A total of 195 subjects, including 68 STEMI patients, 84 patients with stable angina pectoris (SAP) and 43 non-CVD patients, were enrolled in the study. Metabolomic profiling involving the quantitative analysis of 87 endogenous metabolites in plasma was conducted. This study is the first to perform targeted metabolomic profiling in patients with STEMI. We identified 36 significantly altered metabolites in STEMI patients. Increased levels of four amino acids, eight acylcarnitines, six metabolites of the NO-urea cycle and neurotransmitters, and three intermediates of tryptophan metabolism were detected. The following metabolites exhibited decreased levels: six amino acids, three acylcarnitines, three components of the NO-urea cycle and neurotransmitters, and three intermediates of tryptophan metabolism. We found that the significant changes in tryptophan metabolism observed in STEMI patients-the increase in anthranilic acid and tryptophol and decrease in xanthurenic acid and 3-OH-kynurenine-may play important roles in STEMI pathogenesis. On the basis of the differences in the constructed weighted correlation networks, new significant metabolite ratios were identified. Among the 22 significantly altered metabolite ratios identified, 13 were between STEMI patients and non-CVD patients, and 17 were between STEMI patients and SAP patients. Seven of these ratios were common to both comparisons (STEMI patients vs. non-CVD patients and STEMI patients vs. SAP patients). Additionally, two ratios were consistently observed among the STEMI, SAP and non-CVD groups (anthranilic acid: aspartic acid and GSG (glutamine: serine + glycine)). These findings provide new insight into the diagnosis and pathogenesis of STEMI.

引用

页数：17

共 34 条

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