Association of adipose tissue inflammation and physical fitness in older adults

被引:1
作者
Tylutka, Anna [1 ]
Morawin, Barbara [1 ]
Torz, Natalia [2 ]
Osmolska, Joanna [2 ]
Luszczki, Kacper [2 ]
Jarmuzek, Pawel [3 ]
Zembron-Lacny, Agnieszka [1 ]
机构
[1] Univ Zielona Gora, Dept Appl & Clin Physiol, Coll Med, 28 Zyty Str, PL-65417 Zielona Gora, Poland
[2] Univ Zielona Gora, Coll Med, Student Res Grp, 28 Zyty Str, PL-65417 Zielona Gora, Poland
[3] Univ Zielona Gora, Neurosurg Ctr, Dept Nervous Syst Dis, Univ Hosp Zielona Gora,Coll Med, Zielona Gora, Poland
关键词
Physical fitness; Older adults; Proinflammatory cytokine; Adipose tissue; Adipokine; NUTRITIONAL RISK INDEX; SERUM LEPTIN CONCENTRATIONS; BODY-FAT DISTRIBUTION; GAIT SPEED; INSULIN SENSITIVITY; PLASMA ADIPONECTIN; ELDERLY-PATIENTS; ACUTE EXERCISE; RENAL-FUNCTION; OBESITY;
D O I
10.1186/s12979-024-00468-7
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
An active lifestyle is of key importance for reduction of obesity and inflammation, as well as circulating levels of adipokines. Therefore, the aim of our study was to assess the relationship of physical fitness with chronic inflammatory status, and to evaluate biomarkers useful in the analysis of adipose tissue dysfunction. Sixty-three older adults (69.6 +/- 5.1 years) were allocated to a high n = 31 (women n = 23 and men n = 8 male) or low physical fitness n = 32 (women n = 29 and men n = 3) group based on gait speed values (1.4-1.8 m/s or <= 1.3 m/s). The gait speed correlated with hand grip strength (r(s) = 0.493, p = 0.0001) and with leptin level (R = -0.372, p = 0.003), which shows the benefits of physical activity on muscle strength and circulating adipokines. In low physical fitness group, 58.1% individuals had adiponectin to leptin ratio (Adpn/Lep) < 0.5 revealing dysfunction of adipose tissue and high cardiometabolic risk; 20% of the group were obese with BMI >= 30 kg/m(2). In high physical fitness group, 25.8% of individuals had Adpn/Lep >= 1.0 i.e., within the reference range. Markers of systemic inflammation were significantly related to physical fitness: CRP/gait speed (r(s) = -0.377) and HMGB-1/gait speed (r(s) = -0.264). The results of the ROC analysis for Adpn (AUC = 0.526), Lep (AUC = 0.745) and HMGB-1 (AUC = 0.689) indicated their diagnostic potential for clinical prognosis in older patients. The optimal threshold values corresponded to 1.2 mu g/mL for Adpn (sensitivity 74.2%, specificity 41.9%, OR = 1.4, 95%Cl 0.488-3.902), 6.7 ng/mL for Lep (sensitivity 56.2%, specificity 93.5%, OR = 14.8, 95%Cl 3.574-112.229), 2.63 mg/L for CRP (sensitivity 51.6%, specificity 84.3%, OR = 4.4, 95% Cl 1.401- 16.063) and 34.2 ng/mL for HMGB-1 (sensitivity 62.0%, specificity 86.6%, OR = 12.0, 95%Cl 3.254-61.614). The highest sensitivity and specificity were observed for Leptin and HMGB-1. The study revealed changes in inflammatory status in older adults at various levels of physical fitness and demonstrated diagnostic usefulness of adipokines in the assessment of adipose tissue inflammation.
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页数:17
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