Component Composition and Antimicrobial Activity of Perovskia Angustifolia Essential Oil

Objective: The component composition of the essential oil (EO) obtained by hydrodistillation from the air-dry and fresh aboveground parts of the plant Perovskia angustifolia Kudr., growing on the territory of the Namangan region of the Republic of Uzbekistan has been studied. Methods: By GC-MS, 57 compounds were identified in the composition of the EO from the air-dried plant, while 46 substances were found in the composition of the EO from the fresh plant, which is 94.0 and 96.2% of the total amount of EOs, respectively. Results and Discussion: The main EO components of both the air-dry and fresh aerial parts are 1,8-cineole, its content is 24.2, and 25.1%, respectively. EO from an air-dry plant contains camphor (8.6%), endoborneol (7.3%), bornyl acetate (6.2%), caryophyllene (4.4%), alpha-humulene (4.1%), delta-cadinene (3.8%) and other connections. The dominant components in the composition of EO from a fresh plant, in addition to 1,8-cineol, are camphor (13.8%), endoborneol (8.6%), bornyl acetate (7.0%), gamma-terpinene (7.0%), m-cimene (5.2%), Delta-3-karen (4.5%), delta-kadinen (2.9%). The aerial part of P. angustifolia can serve as a rich source of 1,8-cineole, which is used in bronchitis, colds of the respiratory tract, chronic and inflammatory respiratory diseases. Conclusions: EO from the aerial part of the air-dry P. angustifolia exhibits a noticeable antimicrobial and antifungal effect against test strains of Gram-positive, Gram-negative bacteria, while gram-positive bacteria Bacillus subtilis and Staphylococcus aureus turned out to be the most sensitive to the effects of essential oil.