Clinical Relevancies of Sarcopenic Obesity in Patients with Metabolic Dysfunction-Associated Fatty Liver Disease (MASLD)

被引：1

作者：

Chien, Shih-Chieh ^{[1
,2
]}

Chiu, Hung-Chih ^{[2
]}

Chiu, Yen-Cheng ^{[2
]}

Wang, Ru-Hsueh ^{[3
]}

Dillera, Karl Paolo O. ^{[4
]}

Lee, Kuo-Ting ^{[5
]}

Tsai, Hung-Wen ^{[6
]}

Tsai, Yau-Sheng ^{[1
]}

Ou, Horng-Yih ^{[2
]}

Cheng, Pin-Nan ^{[2
]}

机构：

[1] Natl Cheng Kung Univ, Coll Med, Inst Clin Med, Tainan 70401, Taiwan

[2] Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Dept Internal Med, 138 Sheng Li Rd, Tainan 70403, Taiwan

[3] Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Dept Family Med, Tainan 704, Taiwan

[4] Southern Philippines Med Ctr, Davao, Philippines

[5] Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Dept Surg, Tainan, Taiwan

[6] Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Dept Pathol, Tainan, Taiwan

来源：

DIGESTIVE DISEASES AND SCIENCES | 2025年 / 70卷 / 03期

关键词：

Metabolic dysfunction-associated fatty liver disease; Sarcopenic obesity; Osteopenia; Osteoporosis; Atherosclerotic cardiovascular disease; INSULIN-RESISTANCE; STIFFNESS MEASUREMENT; DIAGNOSIS; MORTALITY; MYOSTATIN; FIBROSIS; ADULTS; RISK;

D O I：

10.1007/s10620-025-08844-z

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

AimSarcopenic obesity (SO) is associated with adverse outcomes in diseased patients. This study aimed to examine the prevalence and risks associated with SO, with a focus on the impact of SO on cardiovascular risk in patients with MASLD.Materials and MethodsIn this cross-sectional study, patients with MASLD were prospectively enrolled. Through dual-energy X-ray absorptiometry (DXA) scans, their body compositions were analyzed to identify who had SO and osteopenia/osteoporosis. The primary aim is to investigate risks associated with SO, followed by analyzing the association between SO and cardiovascular disease (CVD).ResultsTwo hundred and twenty-three patients with MASLD were enrolled. The prevalence of SO was 47.1%, respectively. Patients coexisted with MASLD and SO had increased visceral adipose tissue (VAT), higher fatty liver index (FLI) and fibrosis 4 (FIB-4) score. Regression analysis revealed higher FLI and FIB-4 score, as well as history of hypertension, were risks associated with SO. The 10-year atherosclerotic cardiovascular disease (ASCVD) risk score was higher in patients coexisted with MASLD and SO compared to those without (10.1% vs. 7.3%, p = 0.006). Regression analysis showed that increased VAT and FIB-4 score were associated with raised risk of ASCVD.ConclusionPrevalence of SO in MASLD patients is considerable. The presence of SO also linked to higher risk of ASCVD. Therefore, the recognition of SO in patients with MASLD is important in clinical care.

引用

页码：1190 / 1200

页数：11

共 42 条

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