Functionalized extracellular vesicles of mesenchymal stem cells for regenerative medicine

被引：0
|
作者：
Yoo, Donghyeon [1 ]
Jung, Se Young [1 ]
Go, Dabin [1 ]
Park, Ji Yeong [1 ]
You, Dong Gil [2 ]
Jung, Won-Kyo [3 ,4 ,5 ]
Li, Yuce [6 ]
Ding, Jianxun [7 ]
Park, Jae Hyung [8 ]
Um, Wooram [1 ]
机构：
[1] Pukyong Natl Univ, Coll Fisheries Sci, Dept Biotechnol, Busan 48513, South Korea
[2] Tech Univ Korea, Dept Chem Engn & Biotechnol, Shihung 15073, South Korea
[3] Pukyong Natl Univ, Natl Key Res Inst Univ, Marine Integrated Biomed Technol Ctr, Busan 48513, South Korea
[4] Pukyong Natl Univ, Coll Informat Technol & Convergence, Div Smart Healthcare, Biomed Engn, Busan 48513, South Korea
[5] Pukyong Natl Univ, New Sr Healthcare Innovat Ctr BK21 Plus, Busan 48513, South Korea
[6] Wuhan Univ Sci & Technol WUST, Coll Life Sci & Hlth, Wuhan 430065, Peoples R China
[7] Chinese Acad Sci, Key Lab Polymer Ecomat, Changchun Inst Appl Chem, Changchun 130022, Peoples R China
[8] Sungkyunkwan Univ SKKU, Coll Engn, Sch Chem Engn, Suwon 16419, South Korea
来源：
JOURNAL OF NANOBIOTECHNOLOGY | 2025年 / 23卷 / 01期
基金：
新加坡国家研究基金会;
关键词：
Extracellular vesicle; Exosome; Preconditioning; Nanomedicine; Regenerative medicine; MACROPHAGE POLARIZATION; EXOSOMES; HYPOXIA; REPAIR; PROMOTE; MICRONEEDLES; DYSFUNCTION; PREVENTION; EXPRESSION; MANAGEMENT;
D O I：
10.1186/s12951-025-03300-6
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Stem cell-derived extracellular vesicles (EVs) have emerged as a safe and potent alternative to regenerative medicine in recent decades. Furthermore, the adjustment of EV functions has been recently enabled by certain stem cell preconditioning methods, providing an exceptional opportunity to enhance the therapeutic potential or confer additional functions of stem cell-derived EVs. In this review, we discuss the recent progress of functionalized EVs, based on stem cell preconditioning, for treating various organ systems, such as the musculoskeletal system, nervous system, integumentary system, cardiovascular system, renal system, and respiratory system. Additionally, we summarize the expected outcomes of preconditioning methods for stem cells and their EVs. With recent progress, we suggest considerations and future directions for developing personalized medicine based on preconditioned stem cell-derived EVs.
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页数：20
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