Epigenetic aspects of a putative mechanism of antitumor action of ferrocenylalkylazoles

被引：0
|
作者：
Babin, V. N. [1 ,2 ]
Belousov, Yu. A. [1 ]
Kulikov, V. N. [1 ]
机构：
[1] Russian Acad Sci, AN Nesmeyanov Inst Organoelement Cpds, Bldg 1,28 Ul Vavilova, Moscow 119991, Russia
[2] Sci Res Co Ultrasan, Bldg 4,57 Ul 22 Ya Peschanaya, Moscow 125252, Russia
来源：
RUSSIAN CHEMICAL BULLETIN | 2024年 / 73卷 / 10期
关键词：
ferrocenylalkylazole; epigenetics; tumor transformation; methyl code remodeling; tumor cells; ferrocenylalkylation; DNA; apoptosis; CANCER STEM-CELLS; DNA METHYLATION; TUMOR HETEROGENEITY; HYPOMETHYLATION; METHYLTRANSFERASE; EXPRESSION; RESISTANCE; AUTOPHAGY; PATHWAY; ROLES;
D O I：
10.1007/s11172-024-4397-1
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The results of antitumor assays of ferrocenylalkylazoles and possible mechanisms of their biological activity were analyzed. A model of the antitumor action of ferrocenylalkylazoles was proposed, according to which ferrocenylalkylation of nitrogenous bases of the tumor cell DNA takes place, resulting in a change in the epigenetic regulation and in the initiation of apoptosis.
引用
收藏
页码：2815 / 2820
页数：6
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