Plasmodium falciparum and Schistosoma mansoni coinfections among the general population in Ethiopia: a systematic review and meta-analysis

被引：0

作者：

Setegn, Abebaw ^{[1
]}

Amare, Gashaw Azanaw ^{[2
]}

Abebe, Wagaw ^{[3
]}

Damtie, Wassie Alemayehu ^{[4
]}

Geremew, Gebremariam Wulie ^{[5
]}

Bekalu, Abaynesh Fentahun ^{[5
]}

Alemayehu, Tekletsadik Tekleslassie ^{[6
]}

Megabiaw, Fentahun ^{[1
]}

Wondmagegn, Yenesew Mihret ^{[1
]}

Abriham, Zufan Yiheyis ^{[1
]}

Wassie, Yilkal Abebaw ^{[7
]}

Kibralew, Getasew ^{[8
]}

Girmay, Getu ^{[9
]}

Assefa, Muluneh ^{[10
]}

Mengistie, Berihun Agegn ^{[11
]}

机构：

[1] Univ Gondar, Coll Med & Hlth Sci, Sch Biomed & Lab Sci, Dept Med Parasitol, Gondar, Ethiopia

[2] Debre Markos Univ, Dept Med Lab Sci, Debre Markos, Ethiopia

[3] Woldia Univ, Coll Hlth Sci, Dept Med Lab Sci, Woldia, Ethiopia

[4] Univ Gondar, Coll Med & Hlth Sci, Sch Med, Dept Physiotherapy, Gondar, Ethiopia

[5] Univ Gondar, Coll Med & Hlth Sci, Sch Pharm, Dept Clin Pharm, Gondar, Ethiopia

[6] Univ Gondar, Coll Med & Hlth Sci, Dept Social & Adm Pharm, Gondar, Ethiopia

[7] Univ Gondar, Coll Med & Hlth Sci, Sch Nursing, Dept Med Nursing, Gondar, Ethiopia

[8] Univ Gondar, Coll Med & Hlth Sci, Sch Med, Dept Psychiat, Gondar, Ethiopia

[9] Univ Gondar, Coll Med & Hlth Sci, Sch Biomed & Lab Sci, Dept Immunol & Mol Biol, Gondar, Ethiopia

[10] Univ Gondar, Coll Med & Hlth Sci, Sch Biomed & Lab Sci, Dept Med Microbiol, Gondar, Ethiopia

[11] Univ Gondar, Coll Med & Hlth Sci, Sch Midwifery, Dept Gen Midwifery, Gondar, Ethiopia

来源：

MALARIA JOURNAL | 2024年 / 23卷 / 01期

关键词：

<italic>P. falciparum</italic>; <italic>S. mansoni</italic>; Coinfection; General population; Ethiopia; Systematic review; Meta-analysis; MALARIA; HELMINTH; EPIDEMIOLOGY; INFECTIONS; PREVALENCE;

D O I：

10.1186/s12936-024-05192-7

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

BackgroundDue to the overlapping endemic regions and the high burden of both infections, coinfection with Plasmodium falciparum and Schistosoma mansoni poses distinct public health concerns that require coordinated, multifaceted interventions. There are epidemiological studies on the coinfection of these two parasites in Ethiopia, and the results differ and are inconsistent from one region to another. Thus, the goal of this systematic review and meta-analysis was to ascertain Ethiopia's pooled prevalence of P. falciparum and S. mansoni coinfection.MethodsThe preferred reporting item review and meta-analysis guidelines were followed in this study. PubMed, Google Scholar, Research4Life, Scopus, African-Wider, and EMBASE were the primary search databases. The final analysis included six studies in total. Stata software version 11 was used for analysis after Microsoft Excel was used to extract the data. The critical appraisal tool developed by the Joanna Briggs Institute was used to evaluate the methodological quality of the studies. Publication bias was checked via a funnel plot, Begg's test, and Egger's test. The pooled prevalence of P. falciparum and S. mansoni coinfection was estimated via a random effect model via the Der Simonian-Laird method. The heterogeneity of the studies was evaluated via I2 statistical tests.ResultsThe pooled prevalence of P. falciparum and S. mansoni coinfections in Ethiopia was 10.496% (95% CI 6.134, 14.859). Subgroup analysis of geopolitical regions revealed that the highest and lowest pooled prevalence rates of coinfection were 11.808% (95% CI 0.304, 23.312) and 8.600% (95% CI 5.755, 11.445), respectively, in the Amhara and Benishangul Gumuz regions.ConclusionsThis study highlights the substantial prevalence of P. falciparum and S. mansoni coinfection in Ethiopia's general population, with considerable geographical variation. Targeted and intensive public health interventions are necessary because it has the highest incidence in the Amhara region, and ongoing efforts are needed to address the relatively lower but still considerable prevalence in the Benishangul Gumuz region. These results direct future research, integrated control strategy design, and resource allocation to successfully manage Ethiopia's combined burden of malaria and schistosomiasis.

引用

页数：10

共 42 条

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