Human Pluripotent Stem Cell-Derived Cardiomyocytes for COVID-19 Cardiovascular Complications: A Versatile In Vitro Model for Studying Acute and Chronic SARS-CoV-2 Infection

被引：0

作者：

Lopez-Munoz, Carmen ^{[1
,2
,3
,4
]}

Bowers, Noah Jackson ^{[1
,3
,4
]}

Marchiano, Silvia ^{[1
,3
,4
]}

机构：

[1] Univ Washington, Dept Lab Med & Pathol, Seattle, WA 98195 USA

[2] Columbia Univ, Barnard Coll, New York, NY 10027 USA

[3] Univ Washington, Ctr Cardiovasc Biol, Seattle, WA 98195 USA

[4] Univ Washington, Inst Stem Cell & Regenerat Med, Seattle, WA 98195 USA

来源：

CURRENT TREATMENT OPTIONS IN CARDIOVASCULAR MEDICINE | 2025年 / 27卷 / 01期

关键词：

HPSC-CMs; COVID-19; In vitro models; SARS-CoV-2 cardiac effects; Human pluripotent stem cell-derived cardiomyocytes; Long COVID; MATURATION; DIFFERENTIATION; EXPRESSION; PLATFORM; TROPISM; PROTEIN; TISSUE; MOUSE;

D O I：

10.1007/s11936-025-01079-1

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose of ReviewIn this review, we provide an overview of the benefit, limitations and major findings using human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) for COVID-19 research.Recent FindingsHPSC-CMs offer a highly translational platform for mechanistic and drug screening studies. HPSC-CM models demonstrated that both direct infection and activation of immune response modify the structure, transcriptome and function of cardiomyocytes. Importantly, treatments that block viral infection, replication and/or target inflammation showed promising results in preventing and reducing cardiac damage.SummaryThe cardiac effects of COVID-19 are complex and require robust, cost-effective and scalable models. During the acute phase of infection, results from hPSC-CMs studies improved our understanding of COVID-19 cardiac complications. To better characterize the long-term risk of SARS-CoV-2 infection, in vitro models integrating multiple cell types, bioengineering platforms and in silico analysis are necessary and can inform the development of novel strategies for treating long COVID.

引用

页数：12

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