Managing Chronic Urticaria in Children: An Update

被引:0
作者
Ensina, Luis Felipe [1 ]
Brandao, Larissa [1 ]
Netchiporouk, Elena [2 ]
Bem-Shoshan, Moshe [3 ]
机构
[1] Univ Fed Sao Paulo, Dept Pediat, Div Allergy Clin Immunol & Rheumatol, Sao Paulo, Brazil
[2] McGill Univ Hlth Ctr, Div Dermatol, Montreal, PQ, Canada
[3] McGill Univ Hlth Ctr, Dept Pediat, Div Pediat Allergy Clin Immunol & Dermatol, Montreal, PQ, Canada
关键词
Children; Urticaria; Angioedema; Auto-immunity; Antihistamines; Omalizumab; NATURAL-HISTORY; HYPERSENSITIVITY; OMALIZUMAB; ANGIOEDEMA;
D O I
10.1007/s11882-025-01202-z
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Purpose of ReviewTo provide an update and new insights into the management of pediatric patients with chronic urticaria.Recent FindingsChronic urticaria in children may be more prevalent than previously thought, with a high resolution rate within two years. Patient-reported outcome measures (PROMs) are effective tools for assessing disease severity and control in pediatric populations. Children with chronic urticaria generally respond better to H1-antihistamines compared to adults. For patients refractory to antihistamines, omalizumab has shown excellent efficacy. Additionally, dupilumab has emerged as a potential treatment option, as it has been approved for chronic spontaneous urticaria in some countries.SummaryManaging chronic urticaria in children remains a diagnostic and therapeutic challenge. However, advancements in understanding disease mechanisms, the validation of tools to assess disease activity and control, the development of reliable biomarkers, and the availability of novel therapies offer significant promise. These developments will enable more effective treatment and improved outcomes for pediatric patients.
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页数:8
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