Managing Chronic Urticaria in Children: An Update

被引:0
作者
Ensina, Luis Felipe [1 ]
Brandao, Larissa [1 ]
Netchiporouk, Elena [2 ]
Bem-Shoshan, Moshe [3 ]
机构
[1] Univ Fed Sao Paulo, Dept Pediat, Div Allergy Clin Immunol & Rheumatol, Sao Paulo, Brazil
[2] McGill Univ Hlth Ctr, Div Dermatol, Montreal, PQ, Canada
[3] McGill Univ Hlth Ctr, Dept Pediat, Div Pediat Allergy Clin Immunol & Dermatol, Montreal, PQ, Canada
关键词
Children; Urticaria; Angioedema; Auto-immunity; Antihistamines; Omalizumab; NATURAL-HISTORY; HYPERSENSITIVITY; OMALIZUMAB; ANGIOEDEMA;
D O I
10.1007/s11882-025-01202-z
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Purpose of ReviewTo provide an update and new insights into the management of pediatric patients with chronic urticaria.Recent FindingsChronic urticaria in children may be more prevalent than previously thought, with a high resolution rate within two years. Patient-reported outcome measures (PROMs) are effective tools for assessing disease severity and control in pediatric populations. Children with chronic urticaria generally respond better to H1-antihistamines compared to adults. For patients refractory to antihistamines, omalizumab has shown excellent efficacy. Additionally, dupilumab has emerged as a potential treatment option, as it has been approved for chronic spontaneous urticaria in some countries.SummaryManaging chronic urticaria in children remains a diagnostic and therapeutic challenge. However, advancements in understanding disease mechanisms, the validation of tools to assess disease activity and control, the development of reliable biomarkers, and the availability of novel therapies offer significant promise. These developments will enable more effective treatment and improved outcomes for pediatric patients.
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页数:8
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共 44 条
  • [11] Chronic urticaria in children under 15 years of age: Clinical experience beyond the clinical trials
    Corral-Magana, Oriol
    Antonio Gil-Sanchez, Jose
    Bover-Bauza, Catalina
    Martinez-Cepas, Patricia
    Concepcion Montis-Palos, Maria
    Martin-Santiago, Ana
    [J]. PEDIATRIC DERMATOLOGY, 2021, 38 (02) : 385 - 389
  • [12] Mimickers of Urticaria: Urticarial Vasculitis and Autoinflammatory Diseases
    Davis, Mark D. P.
    van der Hilst, Jeroen C. H.
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 2018, 6 (04) : 1162 - 1170
  • [13] Leukotriene receptor antagonists for chronic urticaria: a systematic review
    de Silva, Nipun Lakshitha
    Damayanthi, Hasitha
    Rajapakse, Anoja Chamarie
    Rodrigo, Chaturaka
    Rajapakse, Senaka
    [J]. ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY, 2014, 10
  • [14] Urticaria and angioedema in children and adolescents: diagnostic challenge
    Ensina, Luis Felipe
    Brandao, Larissa Silva
    Chong Neto, Herberto
    Ben-Shoshan, Moshe
    [J]. ALLERGOLOGIA ET IMMUNOPATHOLOGIA, 2022, 50 : 17 - 29
  • [15] Ensina LF, 2018, PEDIAT ALLERG IMM-UK, V29, P669, DOI 10.1111/pai.12950
  • [16] The clinical response to omalizumab in chronic spontaneous urticaria patients is linked to and predicted by IgE levels and their change
    Ertas, R.
    Ozyurt, K.
    Atasoy, M.
    Hawro, T.
    Maurer, M.
    [J]. ALLERGY, 2018, 73 (03) : 705 - 712
  • [17] Prevalence of chronic urticaria in children and adults across the globe: Systematic review with meta-analysis
    Fricke, Julia
    Avila, Gabriela
    Keller, Theresa
    Weller, Karsten
    Lau, Susanne
    Maurer, Marcus
    Zuberbier, Torsten
    Keil, Thomas
    [J]. ALLERGY, 2020, 75 (02) : 423 - 432
  • [18] Validation of UAS7 among children with chronic spontaneous urticaria
    Gabrielli, Sofianne
    Mule, Pasquale
    Prosty, Connor
    Gooding, Gregory
    Le, Michelle
    Zhang, Lydia
    Netchiporouk, Elena
    Baum, Sharon
    Greenberger, Shoshana
    Ensina, Luis F.
    Lovett, Audrey
    Zhang, Xun
    Ben-Shoshan, Moshe
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 2022, 10 (07) : 1927 - +
  • [19] Levels of depression, anxiety and behavioural problems and frequency of psychiatric disorders in children with chronic idiopathic urticaria
    Herguner, S.
    Kilic, G.
    Karakoc, S.
    Tamay, Z.
    Tuzun, U.
    Guler, N.
    [J]. BRITISH JOURNAL OF DERMATOLOGY, 2011, 164 (06) : 1342 - 1347
  • [20] Remibrutinib demonstrates favorable safety profile and sustained efficacy in chronic spontaneous urticaria over 52 weeks
    Jain, Vipul
    Gimenez-Arnau, Ana
    Hayama, Koremasa
    Reich, Adam
    Carr, Warner
    Tillinghast, Jeffrey
    Dahale, Swapnil
    Lheritier, Karine
    Walsh, Pauline
    Zharkov, Artem
    Hugot, Sophie
    Haemmerle, Sibylle
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2024, 153 (02) : 479 - 486.e4