Inactivation of Equine Arteritis Virus by Indolicidin Peptide

被引：0

作者：

Metz, German Ernesto ^{[1
,2
]}

Azcurra, Miriam Beatriz ^{[3
]}

de Souza, Guilherme Sastre ^{[4
]}

Brasil, Maria Carolina Oliveira de Arruda

Cilli, Eduardo Maffud ^{[5
]}

Lorenzon, Esteban Nicolas ^{[4
]}

机构：

[1] Natl Univ La Plata, Fac Vet Sci, Lab Virol, La Plata, Argentina

[2] CONICET CCT La Plata, La Plata, Argentina

[3] Natl Univ La Plata, Fac Vet Sci, Anim Reprod Res Inst, La Plata, Argentina

[4] Fed Univ Jatai, Inst Hlth Sci, Jatai, GO, Brazil

[5] Sao Paulo State Univ Unesp, Inst Chem, Araraquara, Brazil

来源：

INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS | 2025年 / 31卷 / 03期

关键词：

Indolicidin; Antiviral activity; Equine arteritis virus;

D O I：

10.1007/s10989-025-10698-y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Equine viral arteritis is an economically important contagious disease caused by equine arteritis virus (EAV). Our objective was to evaluate the antiviral activity of indolicidin and K-indolicidin peptides against EAV. We found that indolicidin, but not K-indolicidin, completely inhibits EAV. Furthermore, indolicidin did not affect sperm quality parameters, the primary source of EAV transmission. This is the first report showing the potential of indolicidin as a candidate for use as a therapeutic agent against EAV and an additive in equine semen extenders.

引用

页数：5

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