The conditions that patients with systemic lupus erythematosus should fulfill before pregnancy to optimize outcomes: a large-scale multicenter cohort study from China

被引：0

作者：

Zhang, Xueyang ^{[1
]}

Liu, Lingshan ^{[1
]}

Lin, Shudian ^{[2
]}

Duan, Xinwang ^{[3
]}

Luo, Hui ^{[4
]}

Wang, Yongfu ^{[5
]}

Wu, Zhenbiao ^{[6
]}

Huang, Can ^{[1
]}

Long, Yin ^{[1
]}

Cui, Yixin ^{[1
]}

Shi, Xiaohua ^{[7
]}

Song, Yijun ^{[8
]}

Liu, Juntao ^{[8
]}

Zeng, Xiaofeng ^{[1
]}

Zhao, Jiuliang ^{[1
,9
]}

Li, Mengtao ^{[1
,9
]}

Tian, Xinping ^{[1
,9
]}

机构：

[1] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Rheumatol & Clin Immunol, Beijing, Peoples R China

[2] Hainan Gen Hosp, Dept Rheumatol & Immunol, Haikou, Peoples R China

[3] Nanchang Univ, Dept Rheumatol, Affiliated Hosp 2, Nanchang, Peoples R China

[4] Cent South Univ, Xiangya Hosp, Prov Clin Res Ctr Rheumat & Immunol Dis, Dept Rheumatol, Changsha, Peoples R China

[5] Inner Mongolia Univ Sci & Technol, Affiliated Hosp 1, Dept Rheumatol & Immunol, Baotou Med Coll, Hohhot, Inner Mongolia, Peoples R China

[6] Air Force Mil Med Univ, Dept Rheumatol & Immunol, Tangdu Hosp, Xian, Peoples R China

[7] Peking Union Med Coll Hosp, Dept Pathol, Beijing, Peoples R China

[8] Peking Union Med Coll Hosp, Dept Obstet, Beijing, Peoples R China

[9] Peking Union Med Coll Hosp, Dept Rheumatol & Clin Immunol, 1 Shuaifuyuan,Wangfujing Ave, Beijing 100730, Peoples R China

来源：

ARTHRITIS RESEARCH & THERAPY | 2025年 / 27卷 / 01期

关键词：

Systemic lupus erythematosus; Pregnancy; Obstetrics; EULAR RECOMMENDATIONS; WOMEN; HYDROXYCHLOROQUINE; MANAGEMENT; EXPOSURE; HEALTH;

D O I：

10.1186/s13075-025-03497-9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background Systemic lupus erythematosus (SLE) is frequently associated with a lower rate of live birth and a higher incidence of adverse pregnancy outcomes (APOs), and pregnancy can also increase the risk of SLE flares. Comprehensive preconception assessment is critical for improved pregnancy outcomes in patients with SLE. Unfortunately, no global consensus on the conditions that patients with SLE should fulfill prior to pregnancy has yet been formed. Objective This study aimed to investigate the conditions that patients with SLE should fulfill before pregnancy to optimize outcomes. Study design This was a retrospective study utilizing data from a multicenter Chinese SLE cohort. Information on demographics, obstetric history, SLE activity, clinical manifestations, autoantibody profiles, laboratory parameters, therapeutics, and pregnancy outcomes was collected. Logistic regression was used to explore the optimal conditions. Results The study comprised 347 singleton pregnancies from 332 patients with SLE in total, with a mean maternal age at conception of 30.3 (SD 4.0) years. The analysis revealed that patients who were stable for at least 6 months, had no active vital organ involvement, were on nonfluorinated corticosteroids no more than the dose equivalent to prednisone 7.5 mg per day, and were on hydroxychloroquine displayed a significantly higher incidence of live birth (86.1% vs. 73.7%, p = 0.004) and a markedly decreased risk of APOs (29.4% vs. 52.1%, p < 0.001). Additionally, flares occurred less frequently during pregnancy (14.7% vs. 27.3%, p = 0.009), particularly for severe flares (5.8% vs. 14.8%, p = 0.011). Conclusion This study delineated the conditions that patients with SLE should fulfill before pregnancy, which provides better instructions for clinical practice.

引用

页数：10

共 37 条

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