Systemic barrier dysfunction in type 2 inflammation diseases: perspective in the skin, airways, and gastrointestinal tract

被引：2
作者：
Meng, Juan [1 ,2 ]
Xiao, Hao [1 ]
Xu, Feng [1 ]
She, Xueke [3 ]
Liu, Chuntao [1 ,4 ]
Canonica, Giorgio Walter [5 ,6 ]
机构：
[1] Sichuan Univ, West China Hosp, Dept Allergy, Chengdu, Peoples R China
[2] Sichuan Univ, West China Hosp, Dept Otorhinolaryngol, Chengdu, Peoples R China
[3] Sanofi China Investment Co Ltd, Shanghai Branch, Shanghai 200000, Peoples R China
[4] Sichuan Univ, West China Hosp, Dept Resp Med, Chengdu, Peoples R China
[5] Humanitas Univ, Dept Biomed Sci, Via Rita Levi Montalcini 4, Milan, Italy
[6] IRCCS Humanitas Res Hosp, Asthma & Allergy Unit, Via Manzoni 56, Milan, Italy
来源：
IMMUNOLOGIC RESEARCH | 2025年 / 73卷 / 01期
关键词：
Type; 2; inflammation; Epithelial barrier; IL-4; IL-13; Targeted therapy; INNATE LYMPHOID-CELLS; ATOPIC-DERMATITIS; EPITHELIAL BARRIER; STAPHYLOCOCCUS-AUREUS; IL-13; EXPRESSION; PROTEINS; MODERATE; PATHOPHYSIOLOGY; INTERLEUKIN-4;
D O I：
10.1007/s12026-025-09606-9
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The epithelial barrier in different organs is the first line of defense against environmental insults and allergens, with type 2 immunity serving as a protective function. Genetic factors, and biological and chemical insults from the surrounding environment altered regulate epithelial homeostasis through disruption of epithelial tight junction proteins or dilated intercellular spaces. Recent studies suggest that epithelial barrier dysfunction contributes to pathologic alteration in diseases with type 2 immune dysregulation including (but not limited to) atopic dermatitis, prurigo nodularis, asthma, chronic rhinosinusitis with nasal polyps, and eosinophilic esophagitis. In this review, we summarized current understanding of dysfunction of barrier and its interaction with type 2 inflammation across different organs, and discussed the role of epithelial barrier disruption in the pathogenesis of type 2 inflammation. In addition, recent progresses of emerging barrier restorative therapies are reviewed.
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页数：17
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