Role of ENO1 and its targeted therapy in tumors

被引：2
作者：
Li, Yafei [1 ]
Liu, Lu [1 ]
Li, Bo [1 ]
机构：
[1] Jilin Univ, Hosp Stomatol, Dept Oral Anat & Physiol, Jilin Prov Key Lab Oral Biomed Engn, Changchun 130021, Peoples R China
来源：
JOURNAL OF TRANSLATIONAL MEDICINE | 2024年 / 22卷 / 01期
关键词：
BREAST-CANCER; COLORECTAL-CANCER; C-MYC; ENOLASE; GLYCOLYSIS; GROWTH; EXPRESSION; PROMOTES; PROTEIN; MICROENVIRONMENT;
D O I：
10.1186/s12967-024-05847-8
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
ENO1, also called 2-phospho-D-glycerate hydrolase in cellular glycolysis, is an enzyme that converts 2-phosphoglycerate to phosphoenolpyruvate and plays an important role in the Warburg effect. In various tumors, ENO1 overexpression correlates with poor prognosis. ENO1 is a multifunctional oncoprotein that, when located on the cell surface, acts as a "moonlighting protein" to promote tumor invasion and metastasis. When located intracellularly, ENO1 facilitates glycolysis to dysregulate cellular energy and sustain tumor proliferation. Additionally, it promotes tumor progression by activating oncogenic signaling pathways. ENO1 is a tumor biomarker and represents a promising target for tumor therapy. This review summarizes recent advances from 2020 to 2024 in understanding the relationship between ENO1 and tumors and explores the latest targeted therapeutic strategies involving ENO1.
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页数：17
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