Associations of the gut microbiome and inflammatory markers with mental health symptoms: a cross-sectional study on Danish adolescents

被引:0
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作者
Brown, Aisha Alayna [1 ]
Widdowson, Michael [2 ,3 ]
Brandt, Sarah [2 ]
Mohammadzadeh, Parisa [2 ,4 ,5 ]
Rosenberg, Julie B. [2 ,5 ]
Jepsen, Jens Richardt Mollegaard [5 ,6 ]
Ebdrup, Bjorn H. [4 ,5 ]
Hernandez-Lorca, Maria [2 ,5 ]
Bonnelykke, Klaus [2 ]
Chawes, Bo [2 ,4 ]
Stokholm, Jakob [2 ,3 ,7 ]
Thorsen, Jonathan [2 ]
Ibrahimi, Parvaneh [2 ,3 ,10 ]
Li, Xuanji [8 ,9 ]
Sorensen, Soren Johannes [9 ]
Rasmussen, Morten Arendt [2 ,3 ]
机构
[1] Univ Copenhagen, Dept Publ Hlth, Sect Global Hlth, Copenhagen, Denmark
[2] Univ Copenhagen, Herlev & Gentofte Hosp, Copenhagen Prospective Studies Asthma Childhood, COPSAC, Copenhagen, Denmark
[3] Univ Copenhagen, Dept Food Sci, Copenhagen, Denmark
[4] Univ Copenhagen, Fac Hlth & Med Sci, Dept Clin Med, Copenhagen, Denmark
[5] Univ Copenhagen, Ctr Neuropsychiat Schizophrenia Res CNSR, Mental Hlth Ctr Glostrup, Glostrup, Denmark
[6] Copenhagen Univ Hosp, Child & Adolescent Mental Hlth Ctr, Mental Hlth Serv CPH, Copenhagen, Denmark
[7] Slagelse Hosp, Dept Pediat, Slagelse, Denmark
[8] Univ Zhejiang, Sch Life Sci, Sect Microbiol, Hangzhou, Peoples R China
[9] Univ Copenhagen, Dept Biol, Sect Microbiol, Copenhagen, Denmark
[10] Tech Univ Denmark, Dept Hlth Technol, Lyngby, Denmark
来源
SCIENTIFIC REPORTS | 2025年 / 15卷 / 01期
关键词
Gut microbiome; GlycA; ADHD; Mental health; Neurodevelopmental disorders; Inflammatory biomarkers; SELF-REPORT SCALE; MATERNAL IMMUNE ACTIVATION; SEX-DIFFERENCES; ADHD; DEPRESSION; DIET; OBESITY; ASTHMA; IMPACT; RISK;
D O I
10.1038/s41598-025-94687-7
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder that often persists into adulthood and is accompanied by comorbid mental health problems. This cross-sectional cohort study analyzed 411 18-year-olds from the Danish COPSAC(2000) birth cohort to investigate the relationship between the gut microbiome, fasting and postprandial systemic inflammation, ADHD symptoms, and symptoms of anxiety, stress, and depression. ADHD was assessed using the Adult ADHD Self-Report Scale (ASRS), while depression, stress, and anxiety were evaluated with the Depression, Anxiety, and Stress Scale 21 (DASS-21). Fecal metagenomic data and inflammation levels, measured as glycosylated protein A (GlycA), were analyzed following a standardized meal challenge. In males, higher ADHD symptom scores correlated significantly with increased abundance of a tryptophan biosynthesis pathway (MetaCyc Metabolic Pathways Database) and elevated fasting and postprandial GlycA levels (p < 0.05). While the severity of depression, anxiety, and stress symptoms showed weak associations with GlycA and the gut microbiome, our findings indicate a significant link between ADHD symptoms and postprandial inflammation, warranting further investigation into underlying mechanisms.
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页数:14
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