Advancements in programmed cell death research in antitumor therapy: a comprehensive overview

被引：5

作者：

Wei, Shuxin ^{[1
,3
]}

Han, Chuangye ^{[2
,3
]}

Mo, Shutian ^{[2
]}

Huang, Hailian ^{[1
,3
]}

Luo, Xiaoling ^{[1
,3
,4
]}

机构：

[1] Guangxi Med Univ, Sch Basic Med Sci, Nanning 530021, Peoples R China

[2] Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Nanning 530021, Peoples R China

[3] Guangxi Med Univ, Key Lab Early Prevent & Treatment Reg High Frequen, Minist Educ, Nanning 530021, Peoples R China

[4] Guangxi Med Univ Canc Hosp, Dept Expt Res, Nanning 530021, Peoples R China

来源：

APOPTOSIS | 2025年 / 30卷 / 1-2期

基金：

中国国家自然科学基金;

关键词：

Cell death; Programmed cell death; Tumor; Targeted therapy; APOPTOSIS; INHIBITION; FERROPTOSIS; MECHANISMS; REGULATOR; SURVIVAL; CANCER; HYDROXYCHLOROQUINE; NECROPTOSIS; CANAKINUMAB;

D O I：

10.1007/s10495-024-02038-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cell death is a normal physiological process within cells that involves multiple pathways, such as normal DNA damage, cell cycle arrest, and programmed cell death (PCD). Cell death has been a hot spot of research in tumor-related fields, especially programmed cell death, which is a key form of cell death and is classified into different types according to the mechanism of occurrence, such as apoptosis, autophagy, necroptosis, pyroptosis, ferroptosis, and disulfidptosis. Given the important role of PCD in maintaining tissue homeostasis and inhibiting tumorigenesis and development, more and more basic and clinical studies are devoted to revealing its potential application in anti-tumor strategies. The purpose of this review is to systematically review the regulatory mechanisms of PCD and to summarize the latest research progress of anti-tumor treatment strategies based on PCD.

引用

页码：401 / 421

页数：21

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