Formulation and Evaluation of Transferosmal Gel of Levetiracetam

This research focuses on the creation and assessment of a transferosomal gel containing levetiracetam, a drug used to treat epilepsy. Transferosomes are a novel class of ultradeformable vesicles that facilitate transdermal drug delivery. The main purpose of the experiment was to perfect the transferosomal formulation for maximum drug delivery efficiency and particle size and encapsulation efficiency. A 2(3) factorial design was used to make up and test various formulations. The best formulation produced vesicles of 137 nm and an encapsulation efficiency of 94.32%. Various analytical techniques, including FTIR, SEM, and rheological studies, were used to assess the stability, morphology, and behavior of the gel under stress conditions. The gel exhibited desirable characteristics, including a pH suitable for skin application, good spreadability, and a controlled release profile, with more than 75% drug release over 8 h. Kinetic modeling of drug release suggested that the first-order model best fit the release data, indicating a diffusion-controlled mechanism. The gel exhibited desirable characteristics, including a pH suitable for skin application, good spreadability, and a controlled release profile, with more than 75% medication release over a period of 8 h. Kinetic modeling of drug release suggested that the first-order model best fit the release data, indicating a that the drug release rate is proportional to the concentration of the drug remaining in the system.