Piggybacking on nature: exploring the multifaceted world of porcine β-defensins

被引：1

作者：

Finatto, Arthur Nery ^{[1
]}

Meurens, Francois ^{[2
,3
]}

Costa, Matheus de Oliveira ^{[1
,4
]}

机构：

[1] Univ Saskatchewan, Western Coll Vet Med, Large Anim Clin Sci, Saskatoon, SK S7N 5E2, Canada

[2] Univ Montreal, Fac Vet Med, Swine & Poultry Infect Dis Res Ctr, St Hyacinthe, PQ J2S 2M2, Canada

[3] Univ Saskatchewan, Western Coll Vet Med, Dept Vet Microbiol & Immunol, Saskatoon, SK S7N 5E2, Canada

[4] Univ Utrecht, Fac Vet Med, Dept Populat Hlth, Utrecht, Netherlands

来源：

VETERINARY RESEARCH | 2025年 / 56卷 / 01期

基金：

加拿大自然科学与工程研究理事会;

关键词：

Antimicrobial resistance; infection control; bactericidal activity; immunomodulatory features; swine; sustainability; PEPTIDOGLYCAN RECOGNITION PROTEINS; ANTIMICROBIAL PEPTIDES; IMMUNE-SYSTEM; NK-LYSIN; EXPRESSION; RESISTANCE; FAMILY; CATHELICIDINS; ANTIBIOTICS; INDUCTION;

D O I：

10.1186/s13567-025-01465-4

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Porcine beta-defensins (pBDs) are cationic peptides that are classically associated with the innate immune system. These molecules yield both antimicrobial and immunomodulatory properties, as evidenced by various in vitro and animal trials. Researchers have revealed that enhancing pBD expression can be achieved through dietary components and gene editing techniques in pigs and porcine cell models. This state-of-the-art review aims to encapsulate the pivotal findings and progress made in the field of pBD over recent decades, with a specific emphasis on the biological role of pBD in infection control and its usage in clinical trials, thereby offering a new landscape of opportunities for research aimed at identifying prophylactic and therapeutic alternatives for both swine medicine and translational purposes.

引用

页数：13

共 152 条

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