Clinical Heart Xenotransplantation: A Beat or Two Away?

被引:0
作者
Aljabban, Imad [1 ]
Kim, Jacqueline [1 ]
Jaffe, Ian [1 ]
Khalil, Karen [1 ]
Stern, Jeffrey [1 ]
Smith, Deane E. [5 ]
Montgomery, Robert A. [1 ]
Griesemer, Adam [1 ]
Byrne, Guerard W. [2 ,3 ]
Mcgregor, Christopher G. A. [2 ,3 ]
Reyentovich, Alex [4 ]
Moazami, Nader [5 ]
机构
[1] New York Univ Langone Transplant Inst, New York, NY 10016 USA
[2] Univ Minnesota Twin Cities, Dept Surg, Minneapolis, MN USA
[3] UCL, Inst Cardiovasc Sci, London, England
[4] New York Univ Langone Hlth, Dept Med, Div Cardiol, New York, NY USA
[5] New York Univ Langone Hlth, Dept Cardiothorac Surg, Div Cardiac Surg, New York, NY USA
关键词
Xenotransplantation; Orthotopic heart transplantation; Non-human primate; Brain-dead human decedent; Graft rejection; Zoonosis; Peri-operative care; CELL-FREE DNA; PIG-HEART; INTRAVENOUS IMMUNOGLOBULIN; NONHUMAN PRIMATE; TRANSPLANTATION; REJECTION; XENOANTIBODIES; ACTIVATION; EXPRESSION; SURVIVAL;
D O I
10.1007/s40472-024-00457-1
中图分类号
R61 [外科手术学];
学科分类号
摘要
Purpose of ReviewThis manuscript aims to examine key scientific milestones leading to human decedent studies and the compassionate use of cardiac xenografts in human recipients. It also evaluates the peri-operative considerations necessary before initiating large-scale clinical trials.Recent FindingsThe early functionality of cardiac xenografts in humans was initially demonstrated in two brain-dead human decedents through the transplantation of 10-gene-edited hearts from porcine donors. Subsequently, two living human patients received heart xenografts from similarly constructed pigs. Although both patients developed diastolic heart failure and subsequently lost xenograft function, significant insights were gained regarding patterns of immune rejection and strategies to prevent similar outcomes in the future.SummaryThis review consolidates findings from pre-clinical (non-human primate and decedent) and initial human cardiac xenotransplant studies, emphasizing the peri-operative considerations required before proceeding with clinical trials.
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页数:10
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