Diagnostic efficacy of serum microRNAs in predicting pathology of retroperitoneal lymph node dissection in patients with testicular germ cell tumors: a systematic review and meta-analysis

被引:0
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作者
Kardoust Parizi, Mehdi [1 ,2 ]
Singla, Nirmish [3 ]
Daneshmand, Siamak [4 ]
Heidenreich, Axel [1 ,5 ]
Bagrodia, Aditya [6 ]
Margulis, Vitaly [7 ]
Matsukawa, Akihiro [1 ,8 ]
Tsuboi, Ichiro [1 ,9 ]
Shariat, Shahrokh F. [1 ,7 ,10 ,11 ,12 ,13 ,14 ]
机构
[1] Med Univ Vienna, Vienna Gen Hosp, Dept Urol, Comprehens Canc Ctr, Wahringer Gurtel 18-20, A-1090 Vienna, Austria
[2] Univ Tehran Med Sci, Shariati Hosp, Dept Urol, Tehran, Iran
[3] Johns Hopkins Univ, James Buchanan Brady Urol Inst, Baltimore, MD USA
[4] Univ Southern Calif, Dept Urol, Norris Comprehens Canc Ctr, Los Angeles, CA USA
[5] Univ Hosp Cologne, Dept Urol, Urooncol Robot Assisted & Specialized Urol Surg, Cologne, Germany
[6] Univ Calif San Diego, Dept Urol, San Diego, CA USA
[7] Univ Texas Southwestern Med Ctr, Dept Urol, Dallas, TX 75390 USA
[8] Jikei Univ, Sch Med, Dept Urol, Tokyo, Japan
[9] Shimane Univ, Fac Med, Dept Urol, Matsue, Shimane, Japan
[10] Weill Cornell Med Coll, Dept Urol, New York, NY 10065 USA
[11] Karl Landsteiner Inst Urol & Androl, Vienna, Austria
[12] Charles Univ Prague, Fac Med 2, Dept Urol, Prague, Czech Republic
[13] Univ Jordan, Dept Special Surg, Div Urol, Amman, Jordan
[14] Tabriz Univ Med Sci, Res Ctr Evidence Med, Urol Dept, Tabriz, Iran
关键词
MicroRNA; RPLND; MicroRNA-371a-3p; Testicular cancer; Germ cell tumor;
D O I
10.1007/s00345-025-05571-y
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Purpose To evaluate the diagnostic efficacy of serum microRNAs in predicting pathologic findings of retroperitoneal lymph node dissection (RPLND) in patients with testicular germ cell tumors (TGCT). Methods PUBMED, SCOPUS, and Cochrane Library were searched in August 2024 to identify eligible studies according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA 2020) guidelines. Results Nine studies comprising 603 patients were selected in this review. The pooled sensitivity, specificity, and diagnostic odds ratio (DOR) of microRNA-371a-3p for predicting viable tumor other than pure teratoma in RPLND specimen were 0.76 (95% CI 0.49-0.90), 0.97 (95% CI 0.81-0.99) and 31.75 (95% CI 9.24-109.10), respectively. The pooled sensitivity for primary and post-chemotherapy RPLND (PC-RPLND), were 0.77 (95% CI 0.47-0.93) and 0.73 (95% CI 0.28-0.95), respectively. The pooled specificity for primary and PC-RPLND were 0.92 (95% CI 0.72-0.98) and 0.99 (95% CI 0.62-1.00), respectively. The pooled DOR for primary and PC-RPLND were 13.86 (95% CI 2.97-64.79) and 64.11 (95% CI 13.09-313.98), respectively. The major limitation is the lack of standardization of miR371 testing. Conclusion miR -371a-3p is a relatively sensitive and highly specific marker for predicting viable tumors in RPLND pathologic findings. The DOR was particularly significant for patients who underwent PC-RPLND. While serum microRNAs may be useful in distinguishing viable germ cell tumors from necrosis, fibrosis, and teratomas, their ability to differentiate teratomas from necrosis is limited. Well-designed prospective studies are essential to enhance our understanding of the predictive performance of microRNAs.
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页数:12
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