Larvicidal Efficacies of Nanoliposomes Containing Alpha-pinene, Citral, Camphor, and Thymol Against Aedes aegypti and Anopheles stephensi Mosquito Vectors

被引：2

作者：

Sanei-Dehkordi, Alireza ^{[1
,2
]}

Fereydouni, Narges ^{[3
]}

Agholi, Mahmoud ^{[4
]}

Ziaei, Seyed AhmadReza ^{[5
,6
]}

Azadpour, Zahra ^{[5
,6
]}

Zarenezhad, Elham ^{[3
]}

Osanloo, Mahmoud ^{[7
]}

机构：

[1] Hormozgan Univ Med Sci, Sch Hlth, Dept Biol & Control Dis Vectors, Bandar Abbas, Iran

[2] Hormozgan Univ Med Sci, Hormozgan Hlth Inst, Infect & Trop Dis Res Ctr, Bandar Abbas, Iran

[3] Fasa Univ Med Sci, Noncommunicable Dis Res Ctr, Fasa, Iran

[4] Fasa Univ Med Sci, Sch Med, Dept Med Parasitol & Mycol, Fasa, Iran

[5] Fasa Univ Med Sci, Student Res Comm, Fasa, Iran

[6] Fasa Univ Med Sci, Sch Med, Dept Med, Fasa, Iran

[7] Fasa Univ Med Sci, Sch Adv Technol Med, Dept Med Nanotechnol, Fasa, Iran

来源：

ACTA PARASITOLOGICA | 2025年 / 70卷 / 01期

关键词：

Malaria; Dengue fever; Zika virus; Nanotechnology; Liposome; ESSENTIAL OIL; ANTIOXIDANT; ALBOPICTUS; CARVACROL; BENTH;

D O I：

10.1007/s11686-025-00993-5

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

BackgroundDiseases transmitted by Aedes aegypti or Anopheles stephensi, such as Zika virus, dengue fever, and malaria, pose substantial risks to public health, particularly in tropical areas. Plant-derived compounds have emerged as promising alternatives due to their inherent safety and potential efficiency against mosquitoes. This study aimed to improve the efficacy of certain natural compounds, including alpha-pinene, citral, camphor, and thymol, by developing nanoliposomal formulations.MethodsThe nanoliposomes containing alpha-pinene, citral, camphor, and thymol were prepared using the ethanol injection method and then characterized. Using WHO-recommended guidelines, their larvicidal efficacy was investigated against Aedes aegypti and Anopheles stephensi.ResultsThe nanoliposomes particle sizes were 105 +/- 7, 86 +/- 5, 149 +/- 5, and 135 +/- 8 nm, and zeta potentials were - 25.1 +/- 0.5, -17.2 +/- 1.2, -16.4 +/- 1.6, and - 21.3 +/- 1.7 mV, respectively. In addition, the ATR-FTIR (Attenuated Total Reflectance-Fourier Transform InfraRed) analysis verified the successful loading of the compound. Nanoliposomal compounds exhibited superior performance compared to their non-formulated counterparts in larvicidal bioassays. The nanoliposomes containing thymol showed the highest efficacy, with a Lethal Concentration 50 (LC50) of 20 mu g/mL against Ae. aegypti. Nanoliposomes containing citral exhibited an LC50 of 20 mu g/mL against An. stephensi.ConclusionsThe results suggest that nanoliposomes have the potential to serve as an effective vehicle to improve the efficiency of plant-based larvicides. This could play a significant role in developing sustainable mosquito control strategies.

引用

页数：12

共 63 条

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