Signaling to survive: linear ubiquitination in health and disease

被引：0
|
作者：
Gulustan Celik [1 ]
Nadine Weinelt [1 ]
Sjoerd J. L. van Wijk [1 ]
机构：
[1] Goethe University Frankfurt,Institute for Experimental Pediatric Hematology and Oncology
[2] German Cancer Consortium (DKTK) Partner Site Frankfurt/Mainz and German Cancer Research Center (DKFZ),University Cancer Centre Frankfurt (UCT), University Hospital Frankfurt
[3] Goethe-University,undefined
来源：
BIOspektrum | 2025年 / 31卷 / 1期
关键词：
D O I：
10.1007/s12268-025-2402-3
中图分类号：
学科分类号：
摘要：
Post-translational modification with ubiquitin (Ub) controls protein stability, localization and function and occurs as single entity, or as poly-Ub chains, linked via lysine residues or the N-terminal methionine (M1 poly-Ub). Generated by the linear ubiquitin chain assembly complex (LUBAC) and counteracted by the deubiquitinating enzymes OTULIN and CYLD, M1 poly-Ub controls immune signaling, survival and cell death. Here, we discuss old and new functions of M1 poly-Ub in health and disease.
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页码：32 / 35
页数：3
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